mkk4-specific activator

AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. It selectively activates AMPK in muscle tissue, dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels, and improves insulin resistance in db db diabetic mice. [AMPK activator 4 has hypoglycemic effects.]

Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].

Compound B18 (RyRs activator 4) is an insect ryanodine receptor activator that exhibits larvicidal activity against Mythimna separata with an LC50 value of 1.32 mg/L [1].

Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.

PKM2 Activator 4, a chemical compound, functions as an activator of PKM2 with an activation concentration (AC 50) ranging from 1 to 10 μM. It is primarily utilized in cancer research.

PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].

Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.