ml-323

ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (IC50: 820 nM) as substrates, respectively.

4-Chloroguaiaco (4-Chloro-2-methoxyphenol), a derivative of phenol, exhibits antimicrobial efficacy with minimum inhibitory concentrations (MICs) of 110 μg mL against both Staphylococcus aureus and Escherichia coli [1].