mm-102 tfa

MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5 MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos.

MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with an IC50 of 0.4 μM.

CART(55-102)(rat) TFA, a rat-derived satiety factor, exhibits potent appetite-suppressing properties. This compound is intricately linked to both leptin and neuropeptide Y, playing a crucial role in the regulation of hunger. Moreover, CART(55-102)(rat) TFA has been identified to induce anxiety and stress-related behavior, as documented in studies [1] [2].

MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and a modulator of mixed lineage leukemia (MLL) protein-protein interaction.

CART(55-102)(human) TFA, a human satiety factor, exhibits strong appetite-suppressing activity. It is closely linked with leptin and neuropeptide Y [1] [2].

MM-401 (TFA), an MLL1 H3K4 methyltransferase inhibitor, effectively impedes MLL1 activity (IC 50 = 0.32 µM) by preventing MLL1-WDR5 interaction. It can induce cell cycle arrest, apoptosis, and differentiation, offering potential for MLL leukemia research [1].