BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease.

Tirasemtiv (CK-2017357)(CK 2017357) is a small-molecule fast-skeletal-troponin activator, with a potential treatment for muscle weakness and neuromuscular dysfunction.

Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody targeting the activin type II receptor (ActRII), exhibiting binding affinities (K D) of 1.7 pM for ActRIIB and 434 pM for ActRIIA, respectively. It is employed in the study of pathological muscle loss and weakness [1] [2].

PF-06260414 is a selective androgen receptor modulator or SARM used to treat muscle weakness.