n(peg2c2acid)nbis(peg2propargyl)

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker compound intended for the synthesis of PROTACs [1].

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker and a PEG-based PROTAC linker, used to synthesize 6-OHDA-PEG3-yne, a compound containing 6-OHDA and Propargyl-PEG3-acid[1].

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

Compound 72-1, also known as BCL-xL BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].

VEGFR-2-IN-39 (PROTAC-5), a PROTAC that targets VEGFR-2 with an IC 50 of 208.6 nM, demonstrates low toxicity. It effectively inhibits the proliferation of EA.hy926, a type of HUVEC, in a concentration-dependent manner, achieving an IC 50 value of 38.65 µM [1].

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.

PROTAC EGFR degrader 2 is a potent compound with an IC50 of 4.0 nM, demonstrating strong antiproliferative activity, and a DC50 of 36.51 nM, indicating robust EGFR degradation activity. It is suitable for synthesizing nitroreductase (NTR)-responsive PROTACs [1].

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

Bis (2-bromoethyl) ether, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs.

GID4 Ligand 2 (compound 67) is a selective binder for GID4 with an IC50 of 18.9 μM and a Kd of 17 μM, and can be used for the synthesis of PROTACs [1].

m-PEG-Tos (MW 2000) is a PEG-based linker utilized in PROTACs to join two essential ligands, facilitating the selective protein degradation through the ubiquitin-proteasome system within cells.

rm-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

N-(Azido-PEG2)-N-Boc-PEG4-acid is a polyethylene glycol (PEG)-based linker developed for synthesizing PROteolysis TArgeting Chimeras (PROTACs)[1].

Propargyl-PEG14-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Azide-PEG-azide (MW 5000) is a polyethylene glycol (PEG)-based linker component employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-Mal-N-bis(PEG2-acid) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system in cells.

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5 is a polyethylene glycol-based linker (PEG-PROTAC) suitable for PROTAC development through chemical synthesis [1].

DBCO-(PEG2-Val-Cit-PAB)2 is a dual-cleavable linker used in antibody-drug conjugates (ADCs).

N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs [1].

m-PEG-acrylate (MW 10000) is a polyethylene glycol (PEG)-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

HO-PEG-CH2COOH (MW 3400) is a PEGylated PROTAC linker with a molecular weight of 3400, serving as a PEG-based building block for PROTAC synthesis[1].

HO-PEG-amine (MW 2000) is a PEG-based linker essential for constructing PROTAC molecules. It connects two critical ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

m-PEG-mal (MW 10000) is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-N-amido-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

TAMRA-Azide-PEG-biotin is a PEG-based linker for PROTACs, joining two essential ligands. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

N-(PEG3-acid)-N-bis(PEG3-amine) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative used as a PROTAC linker for PROTAC synthesis[1].

Propargyl-PEG13-acid is a PEG-based linker for PROTACs [joining two essential ligands] crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and can be employed to create ADC inhibitors of Galectin-3 [1].

Acrylate-PEG-OH (MW 3400) is a polyethylene glycol (PEG)-derived PROTAC linker used in PROTAC synthesis[1].

Propargyl-PEG2-N-bis(PEG2) is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs (proteolysis-targeting chimeras).

Fmoc-N-amido-PEG23-acid is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Azide-PEG-azide (MW 10000) is a polyethylene glycol (PEG)-based linker essential for PROTACs synthesis and assembly[1].