n fmoc n' (azido peg4) l lysine

N-Fmoc-N'-(azido-PEG4)-L-Lysine is an alkyl ether-based PROTAC linker frequently used in the synthesis of PROTACs[1].

N-Fmoc-N'-(azido-PEG4)-L-Lysine-PFP ester is an alkyl ether-based linker for PROTACs, facilitating the connection of two essential ligands critical for forming PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.

Azido-PEG4-azide is a PEG-based PROTAC linker used for synthesizing PROTACs.

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride, a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1) programmed cell death ligand 1 (PD-L1) inhibitor, inhibits the PD-1 PD-L1 interaction with an IC50 of 39.2 nM. It contains the target protein PD-1 PD-L1 ligand and PROTAC linker, which can be used to synthesize PROTAC PD-1 PD-L1 degrader-1 and has anticancer activity. Additionally, it serves as a diluent for the preparation of tablets for direct compression.

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

N-Boc-PEG5-bromide is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and serves as a PROTAC linker based on PEG and Alkyl ether.

Azido-PEG4-acrylate is a crosslinker containing an azide group and an acrylate group. The azide group enables Click Chemistry and the acrylate group enables Michael addition. The hydrophilic PEG spacer increases solubility in aqueous media.

BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

N-Boc-PEG5-alcohol is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation through the ubiquitin-proteasome system within cells.

N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker compound commonly used in the construction of PROTACs, or proteolysis-targeting chimeras[1].

N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs [1].

N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker used in PROTAC synthesis [1].

Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs, crucial for connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

OICR-9429-N-C2-NH2, a ligand for WDR5, intermediate 2, serves as a crucial compound in the synthesis of PROTACs.

N-Boc-N-bis(PEG2-OH) is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

N-(PEG1-OH)-N-Boc-PEG2-propargyl is a polyethylene glycol (PEG)-based linker employed in the synthesis of proteolysis targeting chimeras (PROTACs).

N-Boc-N-bis(PEG4-OH) is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-N-amido-PEG2-alcohol is a PEG-based linker for PROTACs [which joins two essential ligands], crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Boc-PEG4)-NH-PEG4-NH-Boc is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker designed for PROTAC synthesis [1].

N-(m-PEG4)-N'-(PEG2-NHS ester)-Cy5 is a polyethylene glycol (PEG) based PROTAC linker used for PROTAC synthesis[1].

N-Boc-PEG16-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Hydroxypropyl-N’-(azide-PEG3)-Cy3 is a polyethylene glycol (PEG)-based linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs) [1].

N-(Propanoic acid)-N-bis(m-PEG12) is a polyethylene glycol (PEG) based linker used in PROTACs synthesis [1].

Boc-N-PEG1-C2-NHS ester, a PEG-based linker, finds utility in PROTAC synthesis[1].

Boc-N-Amido-PEG5-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Boc-N-bis(PEG3-NHS ester) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a polyethylene glycol-based PROTAC linker used in the synthesis of PROTACs.

Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derivative of Estrone that specifically binds to estrogen receptor α (ERα). With a linker, it complexes with the cIAP1 ligand Bestatin, forming SNIPER[1].

N-Boc-PEG4-bromide is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG) derivative used as a PEG-based PROTAC linker for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

N-Boc-PEG9-alcohol is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Fmoc-NH-PEG4-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Azido-PEG4-beta-D-glucose is a polyethylene glycol (PEG)-based linker compound crucial for the efficient synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker incorporating biotin for labeling, making it a versatile tool in PROTAC synthesis[1].

N-(Amino-PEG3)-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

THP-PEG4-Pyrrolidine(N-Me)-CH2OH, a PEG-based PROTAC linker, aids in the synthesis of PROTAC K-Ras Degrader-1[1].

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based linker compound employed in PROTAC synthesis [1].

N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 (chloride) is a polyethylene glycol (PEG)-based PROTAC linker used for synthesizing PROTACs[1].

N-(m-PEG9)-N'-(propargyl-PEG8)-Cy5 is a polyethylene glycol (PEG)-based PROTAC linker designed for synthesizing PROTACs [1].

N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group, primarily used in PROTAC synthesis [1].

N-(Azido-PEG3)-N-Biotin-PEG4-methyl ester is a polyethylene glycol (PEG) derivative utilized as a PROTAC linker for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].

N-(Azido-PEG3)-N-Boc-PEG4-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimeric (PROTAC) linker used in PROTAC synthesis[1].

N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-derived linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5 is a polyethylene glycol (PEG)-based linker frequently used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].