n3-peg2-c2-pfp ester

The N3-PEG2-C2-PFP ester, a nonclaevable 2-unit polyethylene glycol (PEG) linker, is commonly employed in the synthesis of antibody-drug conjugates (ADCs).

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

Compound 72-1, also known as BCL-xL BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].

VEGFR-2-IN-39 (PROTAC-5), a PROTAC that targets VEGFR-2 with an IC 50 of 208.6 nM, demonstrates low toxicity. It effectively inhibits the proliferation of EA.hy926, a type of HUVEC, in a concentration-dependent manner, achieving an IC 50 value of 38.65 µM [1].

YX-2-107 is a selective and potent CDK6-degrading PROTAC with an IC50 value of 4.4 nM.YX-2-107 inhibits RB phosphorylation and FOXM1 expression in vitro, and inhibits the development of Ph+ ALL in rats.YX-2-107 can be used for the prophylaxis and treatment of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). YX-2-107 can be used for the prevention and treatment of Ph chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL).

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.

PROTAC EGFR degrader 2 is a potent compound with an IC50 of 4.0 nM, demonstrating strong antiproliferative activity, and a DC50 of 36.51 nM, indicating robust EGFR degradation activity. It is suitable for synthesizing nitroreductase (NTR)-responsive PROTACs [1].

(R)-Azetidine-2-carboxylic acid, with catalog number T66331 and CAS number 7729-30-8, is a valuable organic compound for life sciences research.

Bis (2-bromoethyl) ether, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs.

GID4 Ligand 2 (compound 67) is a selective binder for GID4 with an IC50 of 18.9 μM and a Kd of 17 μM, and can be used for the synthesis of PROTACs [1].

Bis-PEG7-PFP ester, a PEG-based linker for PROTACs, facilitates the selective degradation of proteins by connecting two essential ligands and utilizing the ubiquitin-proteasome system within cells.

rm-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Endo-BCN-PEG4-PFP ester is a polyethylene glycol (PEG) derivative, specifically designed as a linker for proteolysis-targeting chimeras (PROTACs) [1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker utilized in the synthesis of PROTACs [1].

DBCO-(PEG2-Val-Cit-PAB)2 is a dual-cleavable linker used in antibody-drug conjugates (ADCs).

Fmoc-N-PEG3-CH2-NHS ester is a PEG-based PROTAC linker that aids in the synthesis of PROTACs[1].

Azido-PEG5-PFP ester is a Polyethylene Glycol (PEG) and Alkyl ether-based Proteolysis Targeting Chimera (PROTAC) linker, commonly used for PROTAC synthesis [1].

Fmoc-N-amido-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

N-(Azido-PEG4)-N-bis(PEG4-NHS ester), a PEG-based PROTAC linker, is an essential component in PROTAC synthesis [1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

m-PEG-Lys-NHS ester (MW 40000) is an alkyl ether-based PROTAC linker used in the synthesis of PROTACs [1].

Bis-(N,N'-PEG4-NHS ester)-Cy5 is an alkyl ether-based linker compound used in the synthesis of PROTACs [1].

C-NH-Boc-C-Bis-(C1-PEG1-PFP), a polyethylene glycol (PEG)-derived PROTAC linker, is utilized in the synthesis of PROTACs [1].

Azido-PEG1-PFP ester, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker.

N-(Azide-PEG3)-N'-(PEG4-NHS ester)-Cy5 is a polyethylene glycol (PEG)-derived PROTAC linker, used in the synthesis of PROTACs [1].

PROTAC MDM2 Degrader-2, designed using PROTAC technology, functions as a MDM2 degrader. It consists of a highly potent MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase, facilitating the degradation of MDM2[1].

m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

The PEG-based PROTAC linker, N-(Azido-PEG2)-N-Boc-PEG3-NHS ester, is suitable for the synthesis of PROTACs[1].

N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-(Azido-PEG2)-N-Boc-PEG4-NHS ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis [1].

cIAP1 Ligand-Linker Conjugates 2 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. This compound is particularly useful in the design of SNIPERs [1].

Bis-PEG9-PFP ester is a PEG-based linker for PROTACs [which joins two essential ligands, crucial for forming PROTAC molecules]. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(2-Pyridyldithio)-PEG4-alcohol, a PEG-based PROTAC linker, is used for the synthesis of PROTACs[1].

N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].