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By Target- Apoptosis
- Gamma-secretase(1)
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Results for "
nirogacestat
" in TargetMol Product Catalog- Inhibitors & Agonists2
Nirogacestat
PF-03084014,PF-3084014,PF03084014,PF 03084014
T69351290543-63-3
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
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Nirogacestat dihydrobromide
T382661962925-29-6
Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 334 269 PMID:20363853
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