np 12

Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.

AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.

AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes.

AUNP-12 TFA (NP-12 TFA), a peptide antagonist of the PD-1 signaling pathway, exhibits equipotent antagonism toward PD-L1 and PD-L2, enhancing lymphocyte proliferation and effector functions. It promotes immune activation, shows significant antitumor activity, and holds potential for improved management of immune-related adverse events (irAEs) [1].