ns 21

Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettiiOrg. Lett.21(5)1287-1291(2019)

AFD-21 is a class I antiarrhythmic drug. It binds to sodium channels in their inactivated state and exerts use- and voltage-dependent inhibition of sodium channels with unbinding rates comparable to those of class I antiarrhythmic drugs with moderate kinetics.

Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A, originally isolated from [A. burnettii], that exhibits anticancer activity. It is cytotoxic to NS-1 murine myeloma cells (IC50 = 8.4 μg ml) but not to neonatal foreskin fibroblasts (IC50 > 100 μg ml).

Temiverine hydrochloride monohydrate is an anticholinergic drug with calcium antagonistic activity.