nyasicol 1,2acetonide

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

Nyasicol 1,2-acetonide is a natural product for research related to life sciences. The catalog number is TN4680 and the CAS number is 1432057-64-1.

1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.

4,4'-(Cyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-2-carbaldehydE) is a useful organic compound for research related to life sciences and the catalog number is T64484.

(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, an active compound found in the aerial parts of Angelica sinensis, exhibits significant anti-growth properties against Aeromonas hydrophila. Additionally, it possesses anticoagulative and antibiotic activities [1].

threo-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN5142 and the CAS number is 848031-94-7.

4-(1-Ethoxy-2-hydroxyethyl)benzene-1,2-diol is a useful organic compound for research related to life sciences and the catalog number is T126255.

(2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T66076 and the CAS number is 122350-59-8.

4-C-(Iodomethyl)-1,2-di-O-(1-methylethylidene)-3,5-bis-O-(phenylmethyl)-a-D-ribofuranose is a Carbohydrate Derivative.

4-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol is a useful organic compound for research related to life sciences. The catalog number is T64514 and the CAS number is 174671-88-6.

(S)-1-Benzyl 2-tert-butyl pyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65611 and the CAS number is 16881-39-3.

erythro-1-Phenylpropane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN4002 and the CAS number is 40421-52-1.

4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol is a natural product for research related to life sciences. The catalog number is TN3001 and the CAS number is 577976-26-2.

β-Aflatrem is a natural product of Chloranthus, Chloranthaceae. The catalog number is TN2486 and the CAS number is 20133-19-1. β-Aflatrem can be used as a reference standard.

1-tert-Butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T66754 and the CAS number is 251924-83-1.

N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide is a useful organic compound for research related to life sciences and the catalog number is T67388.

(S)-1-Benzyl 2-methyl pyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65353 and the CAS number is 5211-23-4.

1-Phenylpropane-1,2-dione (Acetyl benzoyl) is a eukaryotic metabolite produced in plant metabolic reactions.

1,2-Epoxy-1-hydroxymethylpyrrolizidine is a useful organic compound for research related to life sciences and the catalog number is T125765.

erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol is a natural product for research related to life sciences. The catalog number is TN4001 and the CAS number is 1280602-81-4.

Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Via generating a transcriptionally active complex with β-catenin, CREB acts as a mediator of Wnt signaling.ICG-001 is an inhibitor of β-catenin/CREB mediated transcription. The direct cellular target of ICG-001 is CREB. the inhibitory IC50of ICG-001 against β-catenin/CREB mediated transcription was 3 μM. ICG-001 treatment at the concentration of 25 μM for 24h significantly increased caspase activity in both colon cancer cell lines SW480 and HCT116 cell lines but not in normal colonic epithelial cells CCD-841Co. In a cell growth inhibition assay, the IC50s of ICG-001 against SW480 and HCT116 cells were 4.43 μM and 5.95 μM, respectively.In a SW620 nude mouse xenograft model, an water-soluble analog of ICG-001 given at the dose of 150 mg/kg i.v. once in every 2 days dramatically suppressed tumor growth. In a bleomycin-induced pulmonary fibrosis mice model, ICG-001 given at the dose of 5 mg/kg per day reversed pulmonary fibrosis. In a rat myocardial infarction model, ICG-001 was administrated subcutaneously at the dose of 50 mg/kg/day for 10 days which significantly improved cardiac contractile function after myocardial infarction in the rats.

(S)-1-Benzyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T66075 and the CAS number is 16217-15-5.

1-Benzyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate is a useful organic compound for research related to life sciences. The catalog number is T65605 and the CAS number is 155075-23-3.