o desmethyl n deschlorobenzoyl indomethacin

O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981) 2.Morgan, A.G.M., Babu, D., Michail, K., et al.An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivityToxicol. Lett.28048-56(2017) 3.Torisu, K., Kobayashi, K., Iwahashi, M., et al.Discovery of new chemical leads for prostaglandin D2 receptor antagonistsBioorg. Med. Chem. Lett.14(17)4557-4562(2004)

O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias.

(1S,4R)-N-DesmethylSertralineHydrochloride is a Serotonin transporter and Norepinephrine transporter inhibitor with IC50 of 19 nM and 35 nM, respectively.

N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone , a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.

N-desmethyl Eletriptan is a metabolite of eletriptan .1It is formed from eletriptan primarily by the cytochrome P450 (CYP) isoform CYP3A4 in human liver microsomes. 1.Evans, D.C., O’Connor, D., Lake, B.G., et al.Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoproteinDrug Metab. Dispos.31(7)861-869(2003)

N-Boc-O-tosyl hydroxylamine is nitrogen source for the N-amination of aryl and alkyl amines.

N-desmethyl Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.

N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.

O-Desmethyl VU0467485 is a PET precursor of VU0467485.

O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.

N-Desmethyl Clomipramine-d is the deuterium labeled N-Desmethyl Clomipramine.

O-Desmethyl metoprolol, a metabolite of metoprolol, acts as a β1-adrenergic receptor (β1-AR) antagonist. This compound is produced through the metabolism of metoprolol by the cytochrome P450 (CYP) isoform CYP2D6.

N-Desmethyl Clomipramine hydrochloride is a primary plasma N-desmethyl Clomipramine metabolite .

5’-O-(4,4’-Dimethoxytrityl)-2’-O-methyl-5-iodouridine-3’-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1170.

O-Desisobutyl-O-n-propyl Febuxostat, an xanthine oxidase inhibitor.

N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.

N-Desmethyl sildenafil is a major metabolite of sildenafil . N-Desmethyl sildenafil is formed via oxidative metabolism of sildenafil by the cytochrome (CYP) P450 isoforms CYP3A4, CYP3A5, and CYP3A7.

O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma.

N-DMTr-N6-benzoyl-morpholino-A-5’-O-phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1599.

N-DMTr-morpholino-T-5'-O-phosphoramidite is a Nucleoside Phosphoramidite.

N-Trityl-morpholino-T-5'-O-phosphoramidite is a Nucleoside Derivative - Morpholino nucleoside; Phosphoramidite.

Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a useful organic compound for research related to life sciences and the catalog number is T67406.

N-DMTr-N2-isobutyryl-morpholino-G-5’-O-phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1600.

Phthalimide, N-(5-(4-amino-alpha-hydroxy-o-tolyloxy)pentyl)- is a bioactive chemical.

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides.

O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tandem mass spectrometry method for determining carbonic anhydrase inhibitors and their metabolites in urine and hairDrug Test Anal.13(8)1552-1560(2021)

Phosphopeptide; binds to the src SH2 domain.

2’-Deoxy-2’-(N-trifluoroacetyl)amino-5’-O-DMTr-uridine 3’-CED phosphoramidite is a useful organic compound for research related to life sciences. The catalog number is TNU1621 and the CAS number is 126139-44-4.

Mebeverine metabolite O-desmethyl Mebeverine alcohol is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract. Mebeverine metabolite O-desmethyl Mebeverine alcohol is a metabolite of Mebeverine.

N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a polyethylene glycol (PEG) derived linker compound employed in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

N-Desmethyl clozapine-d8 Hydrochloride is a deuterated compound of N-Desmethyl clozapine Hydrochloride. N-Desmethyl clozapine Hydrochloride has a CAS number of 1189888-77-4.

N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite is a Nucleoside Derivative - Morpholino nucleoside; Phosphoramidite.

3'-N-Acetyl-3'-amino-3'-deoxy-2',5'-di-O-acetyluridine is a Nucleoside Derivative - 3'-Modified nucleoside; Amino nucleoside.

N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs).

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a polyethylene glycol-based PROTAC linker employed in PROTAC synthesis.

N-Trityl-N4-benzoyl-morpholino-C-5'-O-phosphoramidite is a Nucleoside Derivative - Morpholino nucleoside; Phosphoramidite.

N,N,O-Tridesmethylvenlafaxine (Tridesmethylvenlafaxine) is a huamn endogenous metabolite.

Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].

o-Anisamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical.

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based linker compound utilized for PROTAC synthesis[1].

5’-O-DMTr-2’-OMe-5MeU-P-methyl phosphonamidite; 5’-O-DMTr-2’-O-methyl-5-methyluridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite is a useful organic compound for research related to life sciences and the catalog number is TNU1620.

7-O-Acetylintermedine N-oxide is a useful organic compound for research related to life sciences and the catalog number is T124401.

N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil . It is formed through dealkylation by the cytochrome P450 (CYP) isoform CYP2D6. It inhibits human ether a go-go (hERG) channels (IC50 = 1.5 μM in HEK293 cells expressing hERG).

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

Phthalimide, N-(5-(4-amino-o-tolyloxy)pentyl)- is a bioactive chemical.

N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 serves as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs[1].

O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM,and is a major circulating metabolite of Apixaban in humans.

N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.