p53 and mdm2 proteinsinteractioninhibitor (racemic)

The racemic p53 and MDM2 proteins-interaction-inhibitor is an inhibitor of the interaction between p53 and MDM2 proteins.

2-Amino-p-cresol is an intermediate for the synthesis of a variety of compounds, including drugs, dyes, etc.; it is also used as a reagent for the synthesis of various polymers and an enzyme inhibitor.

p-(2-Methoxyethyl) phenol, an important kind of pharmaceutical intermediates, is primarily used in the synthesis of metoprolol which is effective drugs in the therapy of cardiovascular disease.

p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.

(2S)-1-O-p-coumaroyl-2-O-acetyl-3-O-β-D-glucopyranosylglycerol is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

N,N-Bis(2-hydroxyethyl)-p-phenylenediamine is an intermediate compound.

P-2'-deoxyribose (P-Nucleoside) is a deoxyribose that is widely found in organisms.

Vitexin 2''-O-p-coumarate (Vitexin2''-O-p-coumarate) is found in fenugreek seeds and promotes 2BS cell proliferation induced by H2O2.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-morpholinoethyl)-, hydrochloride is a bioactive chemical.

Acetamide, 2-chloro-N-(2-hydroxyethyl)-N-(p-(methylsulfonyl)benzyl)- is a bioactive chemical.

m-Dioxan-5-amine, 2-(p-chlorophenyl)-5-methyl- is a bioactive chemical.

2-Furamide, N-(5-(p-aminophenoxy)pentyl)- is a bioactive chemical.

Acetamide, N-(5-(p-aminophenoxy)pentyl)-2-phenyl- is a bioactive chemical.

Apigenin 4'-O-(2'',6''-di-O-E-p-coumaroyl)glucoside is a natural product for research related to life sciences. The catalog number is TN6304 and the CAS number is 71781-79-8.

Acetamide, 2-(p-butoxyphenoxy)-N-(2-(dimethylamino)ethyl)-N-(m-ethoxyphenyl)-, hydrochloride is a bioactive chemical.

4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile is a useful organic compound for research related to life sciences and the catalog number is T66379.

2-Allyl-p-cresol is a biochemical.

Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside (Quercetin 3-O-beta-(6''-p-coumaroyl)glucopyranosyl(1->2)-alpha-L-rhamnopyranoside) is a compound extracted from the leaves of Ginkgo biloba with notable antioxidant properties.

p53-MDM2-IN-1 (Example 30), an inhibitor of the p53-MDM2 X protein interaction, exhibits a K i value of 23.35 µM and holds potential for applications in anti-tumor research.

Spexin-2 (53-70), human, mouse, rat (NPQ 53-70), is a biologically active, non-amidated peptide derived from the prohormone proNPQ, conserved across mammalian species. It centrally modulates cardiovascular and renal function, with observed effects in rats including decreased heart rate and increased urine flow rate.

Aloenin-2'-p-coumaroyl ester, extracted from Aloe vera leaves, is a natural product with potential for inflammation research [1].

Ethanol, 2-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical.

Benzoic acid, m-(2-(p-bromophenyl)-5-methylpyrrol-1-yl)- is a bioactive chemical.

4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T64550 and the CAS number is 1061214-06-9.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(1-methyl-2-piperidino)ethyl- is a bioactive chemical.

2-p-Tolylnaphtho[2,3-d]oxazole-4,9-dione is a Heterocyclic Compound and can be used in anticancer and antimicrobial studies.

5’-O-DMTr-2’-OMe-5MeU-P-methyl phosphonamidite; 5’-O-DMTr-2’-O-methyl-5-methyluridine-3’-O-(P-methyl-N,N-diisopropylamino) phosphonamidite is a useful organic compound for research related to life sciences and the catalog number is TNU1620.

MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.

rel-MDM2/4-p53-IN-3 is an MDM2/4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2/4-p53-IN-3 can be used to study cancers, such as colon cancer.

Pyridine, 2-(5-(p-aminophenoxy)pentyloxy)- is a bioactive chemical.

Benzamide, N-(5-(p-((2-methoxyethyl)amino)phenoxy)pentyl)- is a bioactive chemical.

Acetamide, 2,2-dichloro-N-(2-hydroxyethyl)-N-(p-(methylthio)benzyl)- is a bioactive chemical.

Vitexin-2''-O-p-trans-coumarate is a useful organic compound for research related to life sciences and the catalog number is T126181.

ARS-CoV-2-IN-53 (Compd 5d) shows an inhibitory effect on SARS-CoV-2 replication with an EC50 value of 14.3 μM and exhibits significant antiviral activity against human coronavirus 229E (HCoV-229E) [1].

P-gp BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-proliferative impact of Doxorubicin in the drug-resistant HT29 DX and MDCK-MDR1 human adenocarcinoma colon cancer cell lines [1].

2-Amino-6-chloropurine-9-beta-D-(2'-deoxy-3',5'-di-(O-p-toluoyl))riboside is a 2'-deoxy nucleoside and halo-nucleoside.

Nucleoside Derivatives - Fluoro-modified nucleoside; Halo-nucleoside

p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant double-strand breaks and upregulating the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2 M phase. It induces apoptosis, reduces anti-apoptosis proteins Bcl-2, Bcl-xL, and cyclin B1 levels, and shows anti-proliferative activity against MGC-803 cells with an IC50 of 1.73 μM. Additionally, p53 Activator 2 exhibits potent anticancer effectiveness in MGC-803 xenograft tumor models [1].

Antimicrobial agent.

Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside, an acylated kaempferol glucoside, can be extracted from the leaves of O. dentata and serves as a repellent for the fouling organism, the blue mussel M. edulis [1].

2-Methyl-6-(p-tolyl)heptane-2,3-diol is a natural product for research related to life sciences. The catalog number is TN2778 and the CAS number is 117421-22-4.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-2-O-acetyl-5-(O-p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1038.

(S,E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol is a useful organic compound for research related to life sciences and the catalog number is T125520.

Super-chelating agent & MRI contrast agent

Phthalimide, N-(2-(p-aminophenoxy)ethyl)-, methanesulfonate is a bioactive chemical.

Nucleoside Derivatives - 2’-Modified nucleosides, 7-Deaza-purine nucleosides, Halo-nucleosides

4-Chloro-5-iodo-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1024.

Acetamide, N-(m-anisyl)-2-(p-butoxyphenoxy)-N-(2-(diethylamino)ethyl)-, hydrochloride is a bioactive chemical.

Acetic acid, dichloro-, 2-(2,2-dichloro-N-(p-(methylsulfonyl)benzyl)acetamido)ethyl ester is a bioactive chemical.