pcsk9-in-10

PCSK9-IN-10, a potent and orally active inhibitor of Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9), exhibits a half-maximal inhibitory concentration (IC50) of 6.4 µM. By enhancing the expression of Low-Density Lipoprotein Receptor (LDLR) protein and reducing PCSK9 expression, PCSK9-IN-10 effectively decreases atherosclerosis progression. This compound holds promise for hyperlipidemia research applications.

Lys-Bradykinin acetate is an endogenous bradykinin receptor agonist.

10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions

cis-9,10-Epoxystearic acid (cis-9,10-Epoxyoctadecanoic acid) is an endogenous component in human urine and blood, produced from oleic acid through enzymic and non-enzymic epoxidation.

9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential applications in anticancer research [1].

1,3-dihydroxy-4-methoxy-10-methylacridin-9-one is a natural product for research related to life sciences. The catalog number is TN2491 and the CAS number is 1189362-86-4.

(±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.

8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol, a chemical component of essential oils from Telekia speciosa, exhibits significant antiproliferative activity against human cancer cell lines in vitro.

9-Deacetyl-9-benzoyl-10-debenzoyl-4beta,20-epoxytaxchinin A is a natural product for research related to life sciences. The catalog number is TN3313 and the CAS number is 227011-48-5.

Aristolan-1(10)-en-9-ol, a sesquiterpene, is derived from the Laurencia similis species [1].

10-Isobutyryloxy-8,9-epoxythymol isobutyrate, a major constituent of Inula helenium and Inula royleana root cultures,

8-Hydroxy-9,10-diisobutyryloxy-thymol, a potent terpenoid found in Inula sericophylla [1], exhibits significant bioactivity.

9(S),10(S),13(S)-TriHOME is an oxylipin derived from linoleic acid. It has been detected in beer and in bronchoalveolar lavage fluid (BALF) from female smokers.

Acridan-9-carboxylic acid, 10-methyl-, 2-(diethylamino)ethyl ester, hydrochloride is a biochemical.

9-Deacetyl-9-benzoyl-10-debenzoyltaxchinin A is a natural product from Taxus baccata L. cv. stricta.

Endogenous bradykinin receptor agonist