piperidin-1-amine hydrochloride

EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.

N-Aminopiperidine hydrochloride (Piperidin-1-amine hydrochloride) is a metabolite (M1) of the canabinoid receptor 1 antagonist Rimonabant, an antiobesity agent.

1-Aminohydantoin hydrochloride is a significant metabolite of furantoin in animal tissues. It binds covalently to tissue proteins, is released under slightly acidic conditions, and can be detected by derivatization with 2-nitrobenzaldehyde forming a nitrophenyl derivative of AHD. It is used in assays to determine veterinary drug residues in meat and milk.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methyl

1-Methyl-1H-pyrazol-3-amine is a pyrazole compound used in the synthesis of various drugs, dyes, and polymers. It serves as a crucial intermediate in drug synthesis and plays a role in developing new drugs, as well as in studying enzyme inhibitors and receptor modulators.

AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

Bis(2-chloroethyl)amine hydrochloride is used as pharmaceutical intermediate.

Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 = 5.7 nM).

Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.

DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity.

NPS ALX Compound 4a hydrochloride(1:1) is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM.

LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM for LMPTP-A.

1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride inhibits L amino acid transporter proteins and the α2δ subunit of voltage-gated calcium channels.1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride can be used as a biological module for the synthesis of active biochemical reagents.

2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine is an indoleamine compound that is structurally similar to serotonin. It is a selective agonist at the 5-HT2A receptor and has potential applications in neuroscience.

1-(2,4-difluorophenyl)guanidine hydrochloride is a compound that is a potent and selective inhibitor of the voltage-gated sodium channel Nav1.7, a key player in pain signaling. It is therefore able to reduce pain signaling, resulting in an analgesic effect.

3-([2,2':5',2'':5'',2'''-quaterthiophen]-5-yl)propan-1-amine FA is a useful organic compound for research related to life sciences and the catalog number is T67824L.

TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress ROS JNK signaling in colon cancer cells.

IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR, effectively inhibiting MVA-induced IFN-α responses by BM-pDCs with an IC50 of 2-8 μM.

1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of Src family kinases v-Src.

mAChR-IN-1 hydrochloride is a potent antagonist of muscarinic cholinergic receptors (mAChR) with an IC50 of 17 nM.

MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1].

Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.

Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) is a synthesized E3 ligase ligand-linker conjugate.

1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.

1-(1-Naphthyl) piperazine hydrochloride (1-naphthalen-1-ylpiperazine hydrochloride) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors.

(S)-3-Amino-1-chloro-5-methylhexan-2-one hydrochloride [catalog number T65276, CAS number 54518-92-2] is a valuable organic compound for life sciences research.

(S)-5-Benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride is a valuable organic compound in life sciences research. Catalog number: T66621; CAS number: 105590-97-4.

(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride, with catalog number T65350 and CAS number 4299-03-0, is a valuable organic compound used in life sciences research.

1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.

1-(2-Chloroethyl)piperidine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66881 and the CAS number is 2008-75-5.

1-Acetyl-4-methylpiperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67190 and the CAS number is 144205-68-5.

1-(2-(4-(Chloromethyl)phenoxy)ethyl)azepane hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66538 and the CAS number is 223251-25-0.

StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells).

3 - (5 '- bromo - [2, 2', 5 ', 2 ', 5 ', 2 '- quaterthiophen] - 5 - yl) propan - 1 - amine is a useful organic compound for research in chemistry and life sciences.

3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66115 and the CAS number is 5409-58-5.

HO-1-IN-1 hydrochloride is a heme oxygenase 1 (HO-1) inhibitor (IC50: 250 nM).

(11aS)-N,N-Diethyl-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences and the catalog number is T64499.

N-(5-((4-(1-Methyl-1H-indol-3-yl)pyridin-2-yl)amino)-2-(piperidin-1-yl)phenyl)acrylamide is a useful organic compound for research related to life sciences and the catalog number is T64835.

2-(Benzyl(methyl)amino)-1-(3-hydroxyphenyl)ethanone hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65560 and the CAS number is 71786-67-9.

(11aR)-N,N-Bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine is a useful organic compound for research related to life sciences and the catalog number is T64794.

H3R-IN-1 Hydrochloride is an inverse agonist of histamine receptor 3( H3R ) .

1-(4-Chlorophenyl)biguanide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67045 and the CAS number is 4022-81-5.

Intermediates and Building Blocks - Nucleophiles; Component: 13822-06-5

Xanthine amine congener (XAC) hydrochloride, a non-selective adenosine receptor antagonist, induces convulsions in mice.

IDO1/2-IN-1 hydrochloride is the first potent dual inhibitor of IDO1 (IC50: 28 nM) and IDO2 (IC50: 144 nM) that is orally active.IDO1/2-IN-1 hydrochloride exhibits antitumor effects.

Liproxstatin-1 hydrochloride is a high-potency ferroptosis inhibitor capable of effectively preventing ferroptotic cell death, with an IC50 value of 22 nM [1].