Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol .

Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to

N-Acetyl-D-Glucosamine (NAG) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc.

Azido Myristic Acid, a click chemistry reagent with an azide group, serves to identify and characterize post-translationally myristylated proteins through a straightforward and robust two-step labeling and detection technique [1].

15-Azido-pentadecanoic acid, also known as Azido Palmitic Acid, serves as a click chemistry reagent due to its azide group. This compound is instrumental in the identification and characterization of post-translationally palmitylated proteins through a straightforward two-step labeling and detection methodology [1]. It can partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules and also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules featuring DBCO or BCN groups, showcasing its versatility in biochemical applications.

CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.

SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).