potassium p-tolyl sulfate

p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver.

Aluminum potassium sulfate (Potassium Aluminium Sulfate) is used in the study of severe acute respiratory syndrome and may be used in the prevention and treatment of cancer.

4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile is a useful organic compound for research related to life sciences and the catalog number is T66379.

7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.

4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T64550 and the CAS number is 1061214-06-9.

4,4,4-Trifluoro-1-(p-tolyl)butane-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T66163 and the CAS number is 720-94-5.

Estrone sulfate potassium is an estrogen ester and conjugate, a natural endogenous steroid.

2-Methyl-6-(p-tolyl)heptane-2,3-diol is a natural product for research related to life sciences. The catalog number is TN2778 and the CAS number is 117421-22-4.

p-Cresyl Sulfate is a major uremic toxin found in the blood of patients with chronic kidney disease (CKD), derived from the metabolites of tyrosine and phenylalanine in the liver.

(S,E)-2-Methyl-6-(p-tolyl)hept-3-en-2-ol is a useful organic compound for research related to life sciences and the catalog number is T125520.

3-(p-Tolyl)-1H-pyrazole is a useful organic compound for research related to life sciences. The catalog number is T67474 and the CAS number is 59843-75-3.

(E)-3-(p-Tolyl)acrylaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66297 and the CAS number is 56578-35-9.

2-(p-Tolyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64839 and the CAS number is 938-94-3.

2-Amino-2-(p-tolyl)acetic acid is a valuable organic compound for life sciences research (catalog number: T66688, CAS number: 13227-01-5).

Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.

Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR), a key regulator of immune-inflammatory conditions. A metabolite of tryptophan derived from dietary protein, it is produced by intestinal bacteria and metabolized in the liver. In chronic kidney disease patients with impaired renal function, it accumulates in serum as a uremic toxin, inducing oxidative stress and accelerating disease progression. At 250 μM, it activates NF-Κb, promoting TGF-β1 and Smad3 expression in rat proximal tubular cells, which is associated with profibrotic activity.

Estradiol 3-sulfate 17β-Glucuronide potassium salt (Estradiol 3-sulfate 17-glucuronide potassium) is a naturally occurring estrogen that competitively inhibits MRP-mediated LTC transporter and can be used to study metabolic diseases.

Indoxyl sulfate is a metabolite of tryptophan, showing adverse effects on bones and the central nervous system, having been most frequently implicated as a contributor to renal disease progression and vascular disease