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(2)
By Target- Apoptosis
- Autophagy(2)
- Ferroptosis(2)
- p53(2)
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Results for "
prima-1
" in TargetMol Product Catalog- Inhibitors & Agonists3
PRIMA-1
2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1
T69545608-24-2
PRIMA-1 (NSC-281668) is a mutant p53 reactivator that induces apoptosis and inhibits the growth of human tumors with mutant p53.
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P53R3
T41068922150-12-7In house
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research.
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Eprenetapopt
APR-246,PRIMA-1Met
T44145291-32-7
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
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