propargyl-peg-6-acid

Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker and a PEG-based PROTAC linker, used to synthesize 6-OHDA-PEG3-yne, a compound containing 6-OHDA and Propargyl-PEG3-acid[1].

Propargyl-PEG10-acid, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG4-Sulfone-PEG4-acid serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1].

Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker frequently utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Propargyl-PEG4-S-PEG4-acid, a polyethylene glycol (PEG)-based PROTAC linker, is suitable for synthesizing Proteolysis Targeting Chimera (PROTACs) [1].

6-Bromohexylphosphonic acid, an alkyl chain-based linker, is commonly used in the synthesis of PROTACs (proteolysis targeting chimeras) [1].

Propargyl-PEG3-phosphonic acid, a PEG-based PROTAC linker, is utilized for PROTAC synthesis[1].

Propargyl-PEG2-acid is a non-cleavable 2-unit PEG ADC linker used in synthesizing antibody-drug conjugates (ADCs)[1].

N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker extensively used in the synthesis of PROTACs (proteolysis targeting chimeras)[1].

6-Maleimidocaproic acid sulfo-NHS serves as an alkyl/ether-based PROTAC linker, facilitating the synthesis of PROTACs.

Propargyl-PEG4-sulfonic acid, a PEG4-based linker compound, is used in PROTAC synthesis[1].

Propargyl-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker compound intended for the synthesis of PROTACs [1].

Propargyl-PEG25-acid is a PEG-based linker used in the formation of PROTAC molecules, connecting two essential ligands to enable selective protein degradation through the ubiquitin-proteasome system within cells.

Propargyl-PEG13-acid is a PEG-based linker for PROTACs [joining two essential ligands] crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG6-(CH2)6-Phosphonic acid functions as a PEG-based PROTAC linker for PROTAC synthesis [1].

Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and can be employed to create ADC inhibitors of Galectin-3 [1].

Propargyl-PEG14-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG4-(CH2)6-Phosphonic acid is a polyethylene glycol-based linker compound designed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

Propargyl-PEG3-phosphonic acid diethyl ester, a PEG-based PROTAC linker, is employed for the synthesis of PROTACs[1].

6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker suitable for synthesizing PROTACs [1].

Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Boc-6-aminohexanoic acid, an alkyl ether-based linker, is utilized in PROTAC synthesis.

Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].