propargyl-peg4-sulfonic acid

Propargyl-PEG4-sulfonic acid, a PEG4-based linker compound, is used in PROTAC synthesis[1].

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid) is a Cereblon ligand with alkyl linker and terminal acid for onward chemistry.

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker and a PEG-based PROTAC linker, used to synthesize 6-OHDA-PEG3-yne, a compound containing 6-OHDA and Propargyl-PEG3-acid[1].

Propargyl-PEG10-acid, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by joining two essential ligands. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG6-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Propargyl-PEG4-Sulfone-PEG4-acid serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1].

m-PEG5-sulfonic acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG2-C2-sulfonic acid, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Boc-NH-PEG3-sulfonic acid, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Carboxy-PEG4-sulfonic acid is a PEG-based linker frequently used in PROTAC synthesis [1].

Boc-PEG2-sulfonic acid is a PEG-based linker for PROTACs, joining two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Bis-PEG3-sulfonic acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker frequently utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Propargyl-PEG4-S-PEG4-acid, a polyethylene glycol (PEG)-based PROTAC linker, is suitable for synthesizing Proteolysis Targeting Chimera (PROTACs) [1].

4-Methyl-4-(methyldisulfanyl)pentanoic acid is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and is designed to be cleavable.

Propargyl-PEG3-phosphonic acid diethyl ester, a PEG-based PROTAC linker, is employed for the synthesis of PROTACs[1].

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker applicable for the synthesis of PROTACs [1].

4-Boc-amino-22-dimethylbutyric acid is an alkyl ether-derived PROTAC linker, suitable for PROTAC synthesis.

Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl ether-based linker suitable for PROTAC synthesis [1].

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker used for the synthesis of PROTACs [1].

Propargyl-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of BTK-IAP PROTACs, including Ibrutinib-based PROTAC 2 and its analogue PROTAC 3. PROTAC 3 induces BTK degradation with a DC50 of 200 nM in THP-1 cells[1].

Azido-PEG2-C2-sulfonic acid is a polyethylene glycol (PEG) derived linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Boc-PEG4-sulfonic acid is a PEG-based linker for PROTACs, facilitating the connection between two essential ligands necessary for PROTAC molecule formation, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker used for synthesizing PROTACs [1].

m-PEG4-sulfonic acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

4-Maleimidobutyric acid, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs[1].

Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1].

Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based PROTAC linker used for synthesizing PROTACs [1].

Propargyl-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Propargyl-PEG3-phosphonic acid, a PEG-based PROTAC linker, is utilized for PROTAC synthesis[1].

Propargyl-PEG2-acid is a non-cleavable 2-unit PEG ADC linker used in synthesizing antibody-drug conjugates (ADCs)[1].

N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker extensively used in the synthesis of PROTACs (proteolysis targeting chimeras)[1].

Bis-PEG4-sulfonic acid is a PEG-based linker for PROTACs, facilitating the conjugation of essential ligands critical for PROTAC molecule formation. It enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs) [1].

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker compound intended for the synthesis of PROTACs [1].

Phenyl-glutarimide 4'-oxyacetic acid, a carboxylic acid-functionalized cerebellar ligand, is utilized in developing PROTAC deactivators due to its superior hydrolytic stability and efficacy. This compound exhibits enhanced binding to PROTAC, [1].

Propargyl-PEG25-acid is a PEG-based linker used in the formation of PROTAC molecules, connecting two essential ligands to enable selective protein degradation through the ubiquitin-proteasome system within cells.

Carboxy-PEG2-sulfonic acid, a polyethylene glycol (PEG)-derived linker, is specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Propargyl-PEG13-acid is a PEG-based linker for PROTACs [joining two essential ligands] crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Propargyl-PEG5-acid is a non-cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and can be employed to create ADC inhibitors of Galectin-3 [1].

Propargyl-PEG14-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

PEG4-sulfonic acid is a PEG-based linker for PROTACs, facilitating the selective protein degradation by connecting two essential ligands necessary for forming PROTAC molecules and leveraging the ubiquitin-proteasome system within cells.

Carboxy-PEG5-sulfonic acid, a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].