proteinase inhibitor e-64

E-64 (Proteinase inhibitor E 64) is an irreversible and specific inhibitor of cysteine proteases, exhibiting an IC50 of 9 nM for papain.

(E Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor demonstrating high antidiabetic efficacy.

(E)-Akt inhibitor-IV ((E)-AKTIV) is an inhibitor of PI3K-Akt.

HIV-1 inhibitor-64 (Compound 7c) is an effective wild-type HIV-1 suppressant, also capable of inhibiting HIV-1 mutants E138K Q148K and G140S Q148R with EC50 values of 62.5 nM and 11.3 nM, respectively. This compound demonstrates antiviral activity and is applicable in AIDS research [1].