pyrene-amido-peg4-azide

Pyrene-amido-PEG4-azide is a PEG-based proteolysis targeting chimera (PROTAC) linker used for the synthesis of PROTACs [1].

Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase ligand-linker conjugate, comprising a Pomalidomide-based cereblon ligand and a linker.

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.

Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) linker compound, designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].

Azide-PEG9-amido-C8-Boc is a polyethylene glycol (PEG) derived linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs [1].

Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Pomalidomide 4'-alkylC6-azide, a Pomalidomide-based cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. It is designed to attach to a protein through a linker, enabling the formation of PROTAC [1].

Pomalidomide 4'-PEG3-azide is a chemically synthesized E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound is utilized in the synthesis of iRucaparib-TP3 (Compound 3), an effective PARP1 degrader developed through the PROTAC strategy and derived from Rucaparib.

Pyrene azide 3 is a PEG-based linker for PROTACs, facilitating the connection between two essential ligands to form PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Azide-PEG-azide (MW 5000) is a polyethylene glycol (PEG)-based linker component employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

TAMRA-Azide-PEG-biotin is a PEG-based linker for PROTACs, joining two essential ligands. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Azide-PEG-azide (MW 10000) is a polyethylene glycol (PEG)-based linker essential for PROTACs synthesis and assembly[1].

Azide-PEG-amine (MW 5000) is a polyethylene glycol (PEG)-derived linker compound with azide functionality, primarily utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

m-PEG-azide (MW 20000) is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands necessary for forming PROTAC molecules, thereby enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Azide-PEG9-amido-C16-Boc is an alkyl ether-based PROTAC linker used in PROTAC synthesis [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

Lenalidomide 4'-alkyl-C5-azide, a functionalized cerebellar ligand designed for PROTAC development, comprises an E3 ligand and an alkyl LC5 ligand featuring terminal azides for coupling with a target protein ligand [1].

Thalidomide-O-amido-PEG-C2-NH2 is a synthesized conjugate formulation designed as an E3 ligase ligand-linker conjugate, incorporating a cereblon ligand based on Thalidomide and a linker component commonly used in PROTAC technology.

Azide-PEG-azide (MW 2000) is a polyethylene glycol (PEG)-based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Azide-PEG-alcohol, a polyethylene glycol (PEG)-based PROTAC linker with a molecular weight of 2000, functions as a versatile option for the synthesis of PROTACs[1].

Azide-PEG-amine (MW 2000) is a Polyethylene Glycol (PEG)-derived linker compound used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Pyrene-amido-PEG4-CH2CH2COOH is a polyethylene glycol (PEG) derived linker specifically designed for constructing proteolysis targeting chimeras (PROTACs)[1].

Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Boc-N-Amido-PEG3-azide is a PEG-based linker used in PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azide-PEG9-amido-C4-Boc is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Boc-N-Amido-PEG2-C2-azide is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Pyrene-PEG2-azide is a PEG-based linker for PROTACs, connecting two essential ligands necessary for PROTAC molecule formation and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-PEG3-azide, a PEG-based linker for PROTACs, joins two essential ligands necessary for forming PROTAC molecules and facilitates selective protein degradation via the ubiquitin-proteasome system within cells.

Lenalidomide 4'-PEG2-azide, a Lenalidomide-derived Cereblon ligand, facilitates the recruitment of CRBN protein. This compound can be tethered via a linker to a protein ligand, enabling the formation of PROTAC [1].

Lenalidomide 4'-alkyl-C3-azide (compound 4a), a chemically modified version of the orally active immunomodulator lenalidomide, is engineered for the synthesis of PROTACs. This compound, serving as a ligand for the ubiquitin E3 ligase cereblon (CRBN), integrates an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups [1].

Azide-PEG9-amido-C12-Boc is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker utilized in PROTAC synthesis[1].

m-PEG-azide (MW 10000), a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG4-azide is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) [1].

Azide-PEG6-amido-C16-Boc is an alkyl ether-based PROTAC linker used in PROTAC synthesis[1].

m-PEG-azide (MW 2000) is a PEG-based linker used in PROTACs to join two essential ligands, facilitating the selective degradation of target proteins through the ubiquitin-proteasome system within cells.

N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a polyethylene glycol (PEG)-based linker compound primarily used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Methyltetrazine-amido-PEG7-azide is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

m-PEG-azide (MW 5000) is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands to enable selective protein degradation via the ubiquitin-proteasome system in cells.

Thalidomide 4'-ether-PEG1-azide, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein. This compound is capable of being linked to a protein ligand via a linker to construct PROTACs [1].