r-secretase modulator 4

IL-17 modulator 4 is a prodrug of IL-17 modulator 1, which is an efficacious modulator of IL-17.

γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.

(S)-2-((R)-3-(4-chlorophenyl)-N’-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-methylbutanamide is a cannabinoid receptor antagonist/inverse agonist.

gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.

γ-Secretase modulator 4 is a potent γ-secretase modulator that reduces Aβ42 levels with IC50s of 0.017 μM in mice and 0.014 μM in humans.

(R)-2-Amino-3-(3,5-dibromo-4-hydroxyphenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66789 and the CAS number is 50299-42-8.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66938 and the CAS number is 331763-66-7.

DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64669.

(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.

(R)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T66999 and the CAS number is 444335-16-4.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

(R)-NVS-ZP7-4 is the R-isomer of NVS-ZP7-4, a Zinc transporter SLC39A7 (ZIP7) inhibitor and the first reported chemical tool to explore the effects of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.

(S)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67269.

(R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a useful organic compound for research related to life sciences. The catalog number is T65902 and the CAS number is 219823-47-9.

(R)-4-[2-(Diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethoxy]phthalazine is a useful organic compound for research related to life sciences and the catalog number is T67274.

Carbohydrate Derivatives; Ready for glycosylation

Compound DL5, also known as Glucocorticoid receptor modulator 4, acts as a conjugate of linkers and glucocorticoid receptor regulators. It demonstrates GRE reporter activity in K562 cells expressing mTNF with an EC50 of 40 μM. Additionally, Compound DL5 binds to anti-tumor necrosis factor (TNF) antibodies and exhibits anti-inflammatory properties in combating arthritis in mouse models.

(R)-2-Amino-2-(4-fluorophenyl)acetic acid, catalog number T67220 and CAS number 93939-74-3, is a valuable organic compound for life sciences research.

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-4-methylpentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65027 and the CAS number is 89536-84-5.

(R)-3-(4-Bromophenyl)-3-((tert-butoxycarbonyl)amino)propanoic acid is a valuable organic compound utilized in life sciences research. It is cataloged under number T65895 and has a CAS number of 261380-20-5.

4 (compound 47) is a highly potent positive allosteric modulator of mGluR2, exhibiting an EC50 value of 0.8 μM, with potential for investigating antipsychotic properties [1].

(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66656 and the CAS number is 10538-59-7.

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65537 and the CAS number is 218608-98-1.

DPP-4 GPR119 modulator 1 (Compound 22) is an orally active compound that acts as both a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist, demonstrating a glucose-lowering effect in blood and moderate inhibition of the hERG channel with an IC50 value of 4.9 µM. This compound is applicable in diabetes research [1].

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is a useful organic compound for research related to life sciences. The catalog number is T66871 and the CAS number is 141942-85-0.

(R)-Boc-4-methoxy-β-Phe-OH, catalog number T65025 and CAS number 500788-87-4, is a valuable organic compound for life sciences research.

(R)-5,7-Difluorochroman-4-ol is a useful organic compound for research related to life sciences. The catalog number is T67112 and the CAS number is 1270294-05-7.

γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM, specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain plasma ratio (Kp, brain = 0.72) in mice [1].

(R)-4-Methoxydalbergione, catalog number TN5798 and CAS number 4646-86-0, is a natural product used in life sciences research.

(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a natural product for research related to life sciences. The catalog number is TN6384 and the CAS number is 1961196-24-6.

(R)-2-Amino-3-(4-fluorophenyl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64973 and the CAS number is 18125-46-7.

(R)-tert-Butyl 2-amino-4-methylpentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66824 and the CAS number is 13081-32-8.

(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid, catalog number T66100 and CAS number 63039-46-3, is a valuable organic compound for life sciences research.

(R)-3-Amino-4-hydroxybutanoic acid, with catalog number T65787 and CAS number 16504-56-6, is a valuable compound for life sciences research.

(R)-Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65936 and the CAS number is 33965-47-8.

(R)-5-Chloro-N-(2-hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)thiophene-2-carboxamide is a useful organic compound for research related to life sciences. The catalog number is T67331 and the CAS number is 721401-53-2.

(R)-2-Amino-3-(pyridin-4-yl)propanoic acid is an essential organic compound for life sciences research, catalog number T67056, CAS number 37535-50-5.

(R)-4-Propyldihydrofuran-2(3H)-one is a useful organic compound for research related to life sciences. The catalog number is T67182 and the CAS number is 63095-51-2.

(R)-2-(4-Ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetic acid is a useful organic compound for research related to life sciences. The catalog number is T65534 and the CAS number is 63422-71-9.

CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arrestin-2 recruitment [1].

(4R,5R,6S)-4-Nitrobenzyl 3-((diphenoxyphosphoryl)oxy)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66253 and the CAS number is 90776-59-3.

4,R-ajmalicine N-oxide is a useful organic compound for research related to life sciences and the catalog number is T124872.

(R)-2-((4-Aminophenethyl)amino)-1-phenylethanol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66549 and the CAS number is 521284-22-0.

Gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSM) that crosses the blood-brain barrier and inhibits the production of the aggregated amyloid β peptide Aβ42 (IC50: 60 nM). This compound is valuable for studying Alzheimer's disease.

(R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(naphthalen-2-yl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65847 and the CAS number is 269398-91-6.

Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-42), addressing diseases associated with Aβ deposition in the brain, particularly Alzheimer's disease.