s trityl l cysteine

S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 μM) and in mouse xenograft models.

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a peptide-cleavable agent-linker conjugate utilized in antibody-drug conjugates (ADCs), with the DM denoting the maytansinoid component [1].

S-(2-Carboxyethyl)-L-cysteine (S-Carboxyethylcysteine), a modified sulfur amino acid, occurs naturally in Acacia seeds. This compound influences protein utilization in rats and suppresses methionine-induced growth rates while adversely affecting plasma amino acid concentrations in these animals [1].

N-Boc-S-benzyl-D-cysteine is a useful organic compound for research related to life sciences. The catalog number is T65543 and the CAS number is 102830-49-9.

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butylthio)-L-cysteine is a useful organic compound for research related to life sciences. The catalog number is T66172 and the CAS number is 73724-43-3.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T67561 and the CAS number is 109425-51-6.

S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine is a useful organic compound for research related to life sciences. The catalog number is T65253 and the CAS number is 19746-37-3.