saikosaponin b 3

Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb- -T cell activation.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.

5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

3-Epimeliasenin B is a natural product for research related to life sciences. The catalog number is TN5953 and the CAS number is 1222475-77-5.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

Nucleoside Derivatives –Fluoro-modified nucleosides, 6-Modified purine nucleosides, 3’-Modified nucleosides

3-epi-Isocucurbitacin B is a natural product for research related to life sciences. The catalog number is TN5972 and the CAS number is 89647-62-1.

Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, functions as an inhibitor of bacterial DNA gyrase B and demonstrates antibacterial activity against Gram-positive strains [1].

hMAO-B-IN-3 (Compound 15) is a potent hMAO-B inhibitor (IC50 = 47.4 nM) with favorable drug-like properties and a broad safety window, making it a suitable candidate for lead optimization and multitarget-directed ligand development [1].

(S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid is an essential organic compound used in life sciences research. The catalog number is T66164 and the CAS number is 72120-71-9.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1039.

Nucleoside Derivatives - Amino-nucleosides, Xylo-nucleosides, 2’,3’-Didexoy nucleosides, 3’-Modified nucleosides

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one is a useful organic compound for research related to life sciences. The catalog number is T65968 and the CAS number is 42399-49-5.

Benzo[b]thiophene-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66350 and the CAS number is 24434-84-2.

3'-b-Amino-2',3'-dideoxy-5'-O-methoxytrityl-5-methyluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-Modified nucleoside; Protected nucleoside with NH2/OH group.

AChE BChE MAO-B-IN-3, an indan-1-one derivative, is a potent inhibitor of human monoamine oxidase B (MAO-B) with an IC50 of 0.0359 μM and also demonstrates significant inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.0473 μM and 0.0782 μM, respectively. Exhibiting notable antioxidant activity, AChE BChE MAO-B-IN-3 holds considerable promise for Alzheimer's disease (AD) research.

3-Hexen-1-ol O-b-D-glucopyranoside is a useful organic compound for research related to life sciences. The catalog number is T123861 and the CAS number is 95632-87-4.

Methyl 8-hydroxy-3-(2-methoxy-2-oxoethyl)-6-methyl-9-oxo-9H-furo[3,4-b]chromene-1-carboxylate is a natural product for research related to life sciences. The catalog number is TN4537 and the CAS number is 96287-41-1.

Kaempferol 3-b-laminaribioside is a useful organic compound for research related to life sciences. The catalog number is T124263 and the CAS number is 75836-21-4.

Nucleosides and Reagents - Fluoro-modified nucleoside; pyridine nucleoside

Nucleoside; Used for nucleoside and nucleic acid modification

AChE/MAO-B-IN-3 is a dual inhibitor targeting both acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), exhibiting inhibitory concentrations (IC50s) of 0.0257 μM and 0.0456 μM against human AChE and MAO-B, respectively. This compound holds potential for Alzheimer’s disease research.

3'-b-Amino-2',3'-dideoxy-5'-O-methoxy trityluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-Modified nucleoside; Protected nucleoside with NH2/OH group.

3-O-[b-D-Apiofuranosyl-(1-2)-[b-D-glucopyranosyl-( is a useful organic compound for research related to life sciences and the catalog number is T131100.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 3’-Modified nucleosides; Fluoro-modified nucleosides

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67294 and the CAS number is 6052-68-2.

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a nucleoside phosphoramidite.

2',3',5'-Tri-O-benzoyl-2'-b-C-methyl-6-azauridine is a nucleoside derivative, specifically a 2'-modified nucleoside of 6-aza-uridine.

Nucleoside Derivatives - 5-Modified pyrimidine nucleoside; 2’-Modified nucleoside; Protected nucleosides with NH2/OH open

6-Amino-3-(furan-2-yl)-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-2-O-acetyl-5-(O-p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1038.

(S)-9-((tert-Butyldimethylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64821.

6-Amino-3-ethynyl-4-methoxy-1-(b-D-ribofuranosyl)-1H- pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

Nucleoside Derivatives - 7-Deazapurine nucleosides; Halo-nucleosides; Scaffolds and Templates

3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.

6-Amino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one is a useful organic compound for research related to life sciences and the catalog number is TNU0282.

(S)-tert-Butyl 2-(3-amino-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate is a useful organic compound for research related to life sciences. The catalog number is T65674 and the CAS number is 109010-60-8.

MAO-B-IN-3 is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and shows affinity for the 5-HT6 receptor with a Ki of 696 nM, making it suitable for Alzheimer's disease research [1].

4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate is an α-arabinopyranosides analogue isolated from the aboveground parts of barley [1].

Quercetin-3-O-β-D-galactopyranosyl-(1→6)-β-D-glucopyranoside (compound 1), a flavonoid glycoside, is extractable from M. delavayi leaves [1].