sds/t5s0313

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

(S)-GNA-T-phosphoramidite is a nucleoside analog commonly used in the synthesis of other active compounds.

(S)-5-chloro-N-(1-((4-chlorophenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-hydroxybenzamide has antifungal and tuberculostatic activities.

S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. S-(5'-Adenosyl)-L-methionine tosylate (SAMe) reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a peptide-cleavable agent-linker conjugate utilized in antibody-drug conjugates (ADCs), with the DM denoting the maytansinoid component [1].

5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE is not a substrate for soybean lipoxygenase. The biological activity of 5(S),6(R)-11-trans DiHETE has not been reported.

5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.

5(S)-Hydroperoxyeicosatetraenoic acid (5(S)-HpETE) is a monohydroperoxy polyunsaturated fatty acid (PUFA) generated by the enzymatic conversion of arachidonic acid via 5-lipoxygenase (5-LO). Subsequently, 5(S)-HpETE undergoes metabolism to form leukotriene A4 (LTA4), which serves as a pivotal intermediate in the synthesis of leukotrienes (LTs).

5(S)-HETE, an endogenous metabolite found in the blood, is utilized in researching Rheumatoid Arthritis, Rhinitis, and Asthma [1] [2].

5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotriene B4 that is weakly chemotactic for PMNL.

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine . It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. 5-hydroxy-6-methoxy (S)-Duloxetine binds to the serotonin (5-HT), norepinephrine, and dopamine transporters with Ki values of 266, 920, and 2,814 nM, respectively.

5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.

(S)-3-Amino-1-chloro-5-methylhexan-2-one hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65276 and the CAS number is 54518-92-2.

Nucleoside Derivatives - 5-Modified pyrimidine nucleosides, Protected nucleosides with NH2/OH open

(S)-Ethyl 2-dodecanamido-5-guanidinopentanoate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67230 and the CAS number is 60372-77-2.

Azido-PEG3-S-PEG4-t-butyl ester is a PEG-based PROTAC linker employed for PROTAC synthesis[1].

N-DMTr-morpholino-T-5'-O-phosphoramidite is a Nucleoside Phosphoramidite.

N-Trityl-morpholino-T-5'-O-phosphoramidite is a Nucleoside Derivative - Morpholino nucleoside; Phosphoramidite.

5-(t-Butyloxycarbonylmethoxy)uridine is a Nucleoside Derivative - 5-Modified pyrimidine nucleoside.

Nucleoside Derivatives - 5-Modified pyrimidine nucleosides,2’-Modified nucleosides; Protected nucleosides with NH2/OH group

(S)-2-((tert-Butoxycarbonyl)amino)-5-guanidinopentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65731 and the CAS number is 13726-76-6.

Super-chelating agent& MRI contrast agent

(S)-5-Benzyl 1-tert-butyl 2-aminopentanedioate hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66621 and the CAS number is 105590-97-4.

(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65350 and the CAS number is 4299-03-0.

5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. There are no literature reports of the biological activity or further metabolic fate of 5(S)-HETrE.

(S)-(-)-5-Fluorowillardiine ((S)-5-Fluorowillardiine) is an AMPA receptor-specific agonist

(S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione is a useful organic compound for research related to life sciences. The catalog number is T65826 and the CAS number is 189028-93-1.

6-S-(2-Cyanoethyl)-2’-deoxy-5’-O-DMTr--6-thioguanosine 3’-CED phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1665.

2',3'-Bis-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethyltriphenylmethyl)uridine is a nucleoside Derivative - Other modified nucleoside.

(S)-DMT-glycidol-T is a Nucleoside Derivative - Acyclic nucleoside.

(S)-3-((S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T66207 and the CAS number is 189028-95-3.

(S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 via a 5- or 6-hydroxy duloxetine intermediate, followed by a catechol duloxetine intermediate. This compound effectively inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) across lipid membranes, with inhibition constants (Kis) of 266, 920, and 2,814 nM, respectively, for human transporters.

1,4-Anhydro-2,3-O-isopropylidene-5-O-t-butyldiphenylsilyl-4-thio-D-ribitol is a Carbohydrate Derivative.

(S)-4-Amino-5-(benzyloxy)-5-oxopentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65330 and the CAS number is 13030-09-6.

(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66210 and the CAS number is 898543-06-1.

3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine, a cytidine analog, inhibits DNA methyltransferases (e.g., Zebularine), exhibiting potential anti-metabolic and anti-tumor activities [1].

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)hexanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66637 and the CAS number is 401915-53-5.

N4-Benzoyl-2',3'-di-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N4-methylcytidine is a nucleoside Derivative - Other modified nucleoside.

5-Bromo-N1-t-butoxycarbonylmethyl-uracil is a PNA-related Derivative.

Nucleoside Derivatives - 6-Modified purine nucleosides; Protected nucleosides w/NH2/OH open

5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit rat basophilic leukemia cell 5-lipoxygenase (IC50 = 27 μM) may be entirely due to the 5(S) isomer, but the enantiomers have not been tested separately.

5-O-t-Butyldiphenyl silyl-2,3-O-isopropylidene-D-ribono-1,4-lactone is a Carbohydrate Derivative.

(S)-2-(5-Amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanamido)acetic acid is a useful organic compound for research related to life sciences. The catalog number is T65503 and the CAS number is 6610-42-0.

5'-DMTr-T-Methyl phosphonamidite is a Nucleoside Derivative - phosphonamidite.

Nucleoside Derivative –4’-Modified nucleosides; Protected nucleosides with NH2/OH group

5'-O-t-Butyldimethylsilyl 2'-deoxy-5-iodo-uridine is a Halo-nucleoside; 2'-deoxy nucleoside.

(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ).

(S)-5-(Benzyloxy)-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65087 and the CAS number is 5680-86-4.

hGluR5 kainate receptor agonist

2',3'-Bis(O-t-butyldimethylsilyl)-4',5'-Didehydro-5'-deoxyuridine is a Nucleoside Derivative - 5'-Modified nucleoside, Didehydro-nucleoside.