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(1)
By Target- ASK
- Apoptosis(1)
- MAPK(1)
- Others(2)
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Results for "
selonsertib
" in TargetMol Product Catalog- Inhibitors & Agonists3
Selonsertib
Cited
GS-4997
T33501448428-04-3
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
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CitedSelonsertib HCl
T706221448428-05-4
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
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