sinomenine

Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.

Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.

Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.

Sinomenine N-oxide is one of the major metabolites of the cyclic metabolic mechanism of Sinomenine.

7(R)-7,8-Dihydrosinomenine, an isoquinoline alkaloid extractable from Sinomenium acutum (Menispermaceae), exhibits anti-osteoclastogenic properties [1].

1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].

14-Episinomenine, an alkaloid, can be isolated from Stephania cepharantha [1].

(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.