skf385 hydrochloride

SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium calmodulin-dependent protein kinase IIγ (CaMKIIγ) AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.

SKF 86466 hydrochloride is an α2-adrenoceptor antagonist.

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1 D5 receptor agonist.

S-(−)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist.

SKF-34288 hydrochloride (3-Mercaptopicolinic acid hydrochloride) is an inhibitor of phosphoenolpyruvate carboxykinase (PEPCK),and inhibits Asn metabolism and results in an increase in amino acids and amides.

(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.