spdp peg7 acid

SPDP-PEG7-acid is a PEG-based linker for PROTACs [Proteolysis-Targeting Chimeras] that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Mal-amido-PEG7-acid (Mal-NH-PEG7-COOH) is a PEG-based PROTAC linker that can be used to synthesize PROTACs.

Amino-PEG7-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Boc-NH-PEG7-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG5-acid is a PEG-based linker for PROTACs, connecting two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs, connecting two essential ligands vital for forming PROTAC molecules and enabling selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

7-Octynoic acid (compound 42) serves as a PROTAC linker for synthesizing various PROTACs, composed of two distinct ligands joined by this linker, where one ligand interacts with an E3 ubiquitin ligase and the other binds to the target protein, leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Boc-7-Aminoheptanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applicaitons. Boc-7-Aminoheptanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Fmoc-7-amino-heptanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

SPDP-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is used for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG24-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, which enables selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-N-amido-PEG7-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Bis-PEG7-acid and bis-PEG6-propionic acid are chemical compounds that serve as linkers in the synthesis of PROTACs and antibody-drug conjugates (ADCs), respectively. Bis-PEG7-acid is a PEG-based PROTAC linker, while bis-PEG6-propionic acid is a cleavable ADC linker[1].

SPDP-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.