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spi--112me

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  • Inhibitors & Agonists
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    TargetMol | Activity
SPI--112Me
T46271243685-62-2
SPI--112Me, a prodrug of SPI-112, preferentially inhibits the PTPase activity of Shp2 over Shp1 and PTP1B by more than 20-fold in cell-free assays.
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SPI-112
T43401051387-90-6
SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.
  • $43
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TargetMol | Citations Cited