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Results for "
sr0813
" in TargetMol Product Catalog- Inhibitor Products1
SR-0813
T402292597186-19-9
SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9. It has an IC 50 of 25 nM and EC 50 of 205 nM for the ENL YEATS domain and an IC 50 of 311 nM and EC 50 of 76 nM (CETSA) for the AF9 YEATS domain. SR-0813 exhibits over 100-fold lower affinity (Kd =3.5 μM) for MAP3K19 compared to ENL YEATS (Kd =30 nM). It can be utilized in acute leukemia research.
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