substance p (14)

Substance P (1-4) is a substance P N-terminal tetrapeptide fragment.

Substance P(1-4) acts as a potent antagonist of neurokinin receptors (NK-R) and regulates normal hematopoiesis, additionally inhibiting the formation of endogenous erythroid colonies (EEC) [1].

[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P acetate is the sole to produce grooming.

Substance P 1-9 aceate is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder.

[D-Trp7,9,10]-Substance P acetate is an analogue of substance P which inhibits ion conductance through nicotinic acetylcholine receptors.

Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

[Sar9]-Substance P acetate is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate ([D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate (96736-12-8 free base)) is a broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

[Sar9,Met(O2)11]-Substance P (NA) is an NK1 receptor agonist.

Substance P (7-11) (Substance P 7-11(TFA)) is a C-terminal fragment of Substance P .

[D-Pro4,D-Trp7,9,10] Substance P (4-11) is a potent antagonist of the tachykinin family of neuropeptides [1].

Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].

[Sar4] Substance P (4-11) is a Substance P agonist and an analog of the C-terminus fragment of Substance P known as Substance P (4-11) [1].

Substance P (alligator), a neuropeptide derived from alligator, possesses a primary structure delineated as Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 [1].

Substance P (4-11), a C-terminal fragment of Substance P, acts as a highly selective agonist for NK1 receptors, demonstrating specificity in its interaction.

Substance P Receptor Antagonist 1 has potential applications in treating gastrointestinal disorders, inflammatory diseases, respiratory conditions, and central nervous system disorders.

[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate is a natural product for research related to life sciences. The catalog number is TN3283 and the CAS number is 117254-98-5.

Substance P (1-9) is a nonapeptide that reduces the inactivation of substance P in the guinea-pig ileum and urinary bladder, and is responsible for various excitatory effects on central and peripheral neurons.

Substance P (3-11), an SP fragment peptide capable of crossing the blood-brain barrier (BBB), induces contraction in guinea pig ileum and facilitates chemotaxis in human monocytes [1] [2] [5].

[DAla4] Substance P (4-11), an analog of Substance P (Substance P), effectively inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin) and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively [1].

Substance P-Gly-Lys-Arg, also referred to as β-Preprotachykinin (58-71), is an analog of Substance P.

Substance P (5-11), the C-terminal heptapeptide derived from Substance P, functions as a neuropeptide that specifically interacts with the NK-1 tachykinin receptor [1].

[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with inhibitory affinities (K_i values) of 1 μM for NK-1, 1.3 μM for NK-2, and approximately 9 μM for NK-3 receptors [1].

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P is a neuropeptide Substance P antagonist [1].

Substance P, Free Acid, is a synthetic analog of native Substance P but lacks its biological activity.

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.

[D-Pro4,D-Trp7,9] Substance P (4-11) acts as a potent Substance P antagonist, significantly reducing plasma aldosterone (ALDO) concentrations[1].

[D-Pro2,D-Phe7,D-Trp9] Substance P, an analogue of Substance P, serves as an inhibitor to its parent compound and indirectly contracts the guinea-pig ileum (GPI) [1] [2].

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK 1 receptor selective agonist.

Substance P TFA (Neurokinin P TFA) is a neuropeptide that functions as both a neurotransmitter and neuromodulator in the central nervous system, specifically targeting the neurokinin 1 receptor (NK1-receptor, NK1R).

Biotin-Substance P acts as a neurotransmitter and neuromodulator in the central nervous system. Neurokinin 1 receptor (NK1R) is the endogenous receptor of Biotin-Substance P.

[Gly11] Substance P, an analog of Substance P itself, functions as a neuropeptide within the CNS, serving dual roles as both a neurotransmitter and neuromodulator [1].

[His11]Substance P, an analog of Substance P (Substance P), functions as both a neurotransmitter and neuromodulator in the central nervous system (CNS) [1].

(D-Arg1, D-Pro2, D-Phe7, D-His9)-Substance P is a selective NK1 receptor antagonist [1].

[Glp6] Substance P (6-11) is an analogue of the native peptide Substance P (6-11), acting on 'septide-sensitive' tachykinin receptors and stimulating the formation of [3H]-inositol monophosphate ([3H]-IP1) in rat urinary bladder, as evidenced by references [1] [2].

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is an analogue of Substance P that acts on the neurokinin 1 receptor (NK1R) in rat brain, similarly to Substance P but with a significantly extended duration of action. This compound selectively enhances dopamine metabolism within the mesencephalon and midbrain cortex, increases motor activity, and facilitates the resumption of addictive agent-seeking behavior in rats [1] [2] [3].

[MePhe8,Sar9] Substance P ([MePhe8-MeGly9] Substance P) is a synthetic analog of Substance P, a neuropeptide that functions as both a neurotransmitter and neuromodulator in the central nervous system (CNS).

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist that effectively inhibits the actions of gold-protein-substance P (GPSP) and substance P (SP), demonstrating its efficacy in neutralizing their effects [1].

[Pro9]-Substance P is a highly effective, reversible, and selective NK-1 tachykinin receptor agonist with an EC50 value of 0.93 nM [1].

[Nle11]-Substance P is a Substance P analog designed to prevent methionine oxidation, found in both the gut and brain, and is responsible for various excitatory effects on central and peripheral neurons.

Substance P (1-7)(TFA) is a fragment of the neuropeptide, substance P (SP).

Substance P (2-11), a fragment peptide of Substance P (SP), exhibits contractile effects on the guinea pig ileum and inhibits the permeation of tritiated SP (3 H SP) across brain microvessel endothelial cell (BBMEC) monolayers [1] [2].

(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P (acetate), an antagonist of Substance P and Bombesin, modulates ocular inflammatory responses triggered by antidromic trigeminal nerve stimulation [1].

[Tyr8,Nle11] Substance P, an analog of Substance P, is primarily a neuron-secreted peptide participating in diverse biological functions such as nociception and inflammation [1].

Substance P (6-11), the C-terminal hexapeptideamide of Substance P, exhibits affinity for the NK-1 tachykinin receptor, leading to motoneuron depolarization and a hypotensive effect [1] [2].

[Glp5,Sar9] Substance P (5-11) is an analogue of Substance P [1].