suppressors

GJ071 oxalate is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.

Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).

USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protein levels of oncoproteins MDM2 and DNMT1 while enhancing the levels of tumor suppressors p53 and p21.

MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leading to the promotion of cancer cell death [1].

GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.

UM729, a novel pyrimidoindole, exhibits an additive effect with AhR antagonists to inhibit differentiation in the majority of AML specimens and works synergistically with Ahr suppressors to hinder AML cell differentiation. It, along with SR1, can serve as a standardized additive in culture media, facilitating research into self-renewal mechanisms and the discovery of new antileukemic drugs via cell-based assays for primary human AML cells.