syy b085 1

SYY-B085-1 is an inhibitor of histone acetyltransferase (HAT).

AChE BChE MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively. [AChE BChE MAO-B-IN-1] had a neuroprotective effect and was not significantly cytotoxic.

Dynorphin B (1-13) acetate acts as an agonist on opioid κ-receptor.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases.

B-Raf IN 1 is an inhibitor of B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM).

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Natural product; inhibitor of protein kinase C

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65682 and the CAS number is 111974-74-4.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside.

5-(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64437.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

1-(b-D-Xylofuranosyl)-N6-(m-trifluoromethyl benzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside, Fluoro-modified nucleoside.

1-Hydroxymethyl-b-carboline is a useful organic compound for research related to life sciences. The catalog number is T125583 and the CAS number is 17337-22-3.

Nucleoside Derivatives - Xylo-nucleosides, Thio-nucleosides

(11aR)-5-(4,5,6,7-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-5H-dibenzo[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64513.

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

Dyrk1A B-IN-1 (compound 3n) is a potent, selective, and cell-permeable inhibitor of DYRK1A and DYRK1B, with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.

1-Amino-8-benzyloxy-9-(b-D-xylofuranosyl)guanine is a Nucleoside Derivative - Xylo-nucleoside; 8-Modified purine nucleoside; Amino nucleoside.

UT-B-IN-1 (UTBINH-14) is a reversible, competitive, and selective inhibitor of the urea transporter-B (UT-B) with IC50 values of 10 nM and 25 nM for human and mouse UT-B, respectively. It exhibits low toxicity and superior selectivity against UT-B compared to UT-A isoforms, enhances urine production, and decreases urine concentration in mice, making it suitable for research on diuretic mechanisms.

Dual AChE-MAO B-IN-1 (compound 15) is a safe, metabolically stable neuroprotective agent. This potent, orally active, CNS-permeable inhibitor demonstrates IC50 values of 550 nM for human AChE and 8.2 nM for MAO-B, indicating low in vitro activity against these enzymes.

Nrf2-ARE hMAO-B QR2 modulator 1, a new resveratrol-based multitarget-directed ligand (MTDL), exhibits a well-balanced MTDL profile: it activates the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibits both hMAO-B and QR2 (IC50s = 8.05 and 0.57 μM), and effectively promotes hippocampal neurogenesis. It exerts neuroprotective and antioxidant actions in both acute and chronic Alzheimer models using hippocampal tissues.

Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.

DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM).

1-(2-C-b-Methyl-b-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyridine nucleoside; 2'-C-Methyl nucleoside.

Dynorphin B (1-13) TFA, an agonist of the opioid κ-receptor.

1-Deacetylnimbolinin B is a natural product from Melia toosendan Sieb. et Zucc.

CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid.

CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31-B interferes with the association between Plasmodium falciparum eIF4A (PfeIF4A) and RNA. Additionally, CR-1-31-B induces apoptosis in neuroblastoma and gallbladder cancer cells [4].

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1039.

(11AS)-5-(4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-5H-dibenzo[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64639.

1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride is a useful organic compound for research related to life sciences and the catalog number is T64494.

1-(b-D-Xylofuranosyl)-N6-isopentenyl adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside.

Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside; 2-Modified purine nucleoside

Artoindonesianin B-1 is a natural product for research related to life sciences. The catalog number is TN3083 and the CAS number is 936006-11-0.

1-(b-D-Ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyrimidine nucleoside.

1-(b-D-Xylofuranosyl)-6-azauracil is a Nucleoside Derivative - Xylo-nucleoside; 6-Aza-uridine.

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a polyethylene glycol-based PROTAC linker used in the synthesis of PROTACs.

ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells.

Nucleoside Derivatives - 7-Deaza-8-aza-purine nucleosides,6-Modified purine nucleosides; Scaffolds and Templates

1-(b-D-Xylofuranosyl)uracil is a Nucleoside Derivative - Xylo-nucleoside.

1-(b-D-Xylofuranosyl)-5-fluorouracil is a nucleoside derivative, specifically a xylo-nucleoside and fluoro-modified nucleoside, characterized by a 5-modified pyrimidine nucleoside structure.

Nucleoside Derivatives - Xylo-nucleosides, 2’-Deoxy-nucleosides; ; Protected nucleosides with NH2/OH group

Dynorphin B (1-13) acts as an agonist on the opioid κ-receptor.

Scillascilloside B-1 is a natural product from Scilla scilloides.