tcf/4

MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, and exhibits anticancer activity [1].

UU-T01 is a selective inhibitor of the β-Catenin T-cell factor 4 (β-catenin Tcf) protein-protein interaction (PPI), exhibiting a Ki value of 3.14 µM, and directly binds to β-catenin with a KD value of 0.531 µM.

Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4 in human osteosarcoma cells [1].

β-catenin-IN-2, a potent inhibitor of β-catenin, is suitable for use in colorectal cancer research.