tcs ox2 29 hcl

TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation.

2-Iminothiolane HCl (Trauts reagent) is a useful RNA-protein crosslinking reagent and an effective thiolation reagent for the introduction of sulphydryl groups into oligosaccharides.

1-(3,4-dihydroxyphenyl)-2-(dimethylamino)ethan-1-one hydrochloride is a cholinergic agent that inhibits choline metabolism, which leads to increased levels of acetylcholine in the brain, which in turn enhances cognitive function and memory.

(2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine hydrochloride is a cyclic amine that is structurally related to amphetamine and has been shown to have significant effects on the central nervous system.

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16 46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in th

(S)-3-AMino-2-Methylpropanoic acid-HCl is an amino acid derivative that can be an agonist of the excitatory neurotransmitter glutamate and affect the nervous system.

2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is the impurity of Agomelatine, an antidepressant.

VEGFR-2-IN-29 is a VEGFR2 inhibitor.

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.

SARS-CoV-2-IN-29 disodium, a diphosphate ester featuring a benzene system and molecular tweezers architecture, demonstrates antiviral efficacy by targeting SARS-CoV-2 with half-maximal inhibitory concentrations (IC50s) of 1.5 μM for virus activity and 1.6 μM for spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, evidenced by a half-maximal effective concentration (EC50) of 3.0 μM [1].

Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis.

pFR-pNA, chromogenic substrate for the determination of plasma kallikrein-like activity. CAS Number (net): 64816-19-9.

SARS-CoV-2-IN-29, a two-armed diphosphate ester featuring a benzene system and molecular tweezers, demonstrates antiviral efficacy with IC50 values of 1.5 μM for SARS-CoV-2 activity and 1.6 μM against spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, as indicated by an EC50 of 3.0 μM [1].

3-(4-Acetylphenyl)-2-Aminopropanoic Acid HCl is a useful organic compound for research related to life sciences. The catalog number is T66736 and the CAS number is 1360436-95-8.

Z-RGR-pNA is a chromogenic substrate for the determination of factor Xa.

Peptide agonist for galanin receptors

CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukemia.

(S)-alpha-Fluoromethylhistidine 2 HCl is a potent irreversible inhibitor of histidine decarboxylase (HDC) and glutathione S-transferase.

COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).

Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and mechanical stimulation in a rat model of carrageenin-induced inflammation when administered at a dose of 2 nmol injected into the nucleus accumbens.[3][4] Galanin (5 μg, i.c.v.) also inhibits acetylcholine release induced by scopolamine in the ventral hippocampus of freely moving rats. [5]

N-terminal galanin fragment used to mediate central cardiovascular effects