tetrazine-ph-nhco-peg-4-alkyne

Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG4-based linker for PROTACs synthesis[1].

Tetrazine-Ph-acid is an alkyl chain-derived PROTAC linker employed in PROTAC synthesis[1].

Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker commonly employed for synthesizing PROTACs[1].

Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].

Pip-alkyne-Ph-COOCH3 is an alkyl-chain based PROTAC linker utilized for the synthesis of PROTAC ARD-266[1].

Tetrazine-Ph-PEG4-Ph-aldehyde is a polyethylene glycol (PEG) derived linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Tetrazine-Ph-NHCO-PEG3-alcohol is a polyethylene glycol (PEG) derived linker specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Tetrazine-Ph-PEG5-NHS ester is a PEGylated N-hydroxysuccinimide (NHS) ester molecule that serves as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-derived linker for PROTACs synthesis.

Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker utilized for PROTACs synthesis[1].

Tetrazine-Ph-OPSS is an ADC linker employed for synthesizing ADCs, or antibody-drug conjugates [1].