tetrazine-ph-peg4-ph-aldehyde

Tetrazine-Ph-PEG4-Ph-aldehyde is a polyethylene glycol (PEG) derived linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-NHS ester is a non-cleavable linker used in antibody-drug-conjugation (ADC).

PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC[1].

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) serves as an E3 ligase ligand-linker conjugate, integrating a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is utilized in PROTAC EED degrader-1, a PROTAC that targets EED with a potency (pKD) of 9.02[1].

Ald-Ph-amido-PEG2 is a noncleavable ADC linker for antibody-drug conjugate[1].

Ald-Ph-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative primarily employed as a noncleavable ADC linker[1].

Ald-Ph-amido-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Tetrazine-Ph-acid is an alkyl chain-derived PROTAC linker employed in PROTAC synthesis[1].

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker utilized for the synthesis of PROTACs, an abbreviation for proteolysis-targeting chimeras[1].

Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

Ald-Ph-PEG12-TFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker employed in the synthesis of PROTACs[1].

Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.

Ald-Ph-amido-PEG3-C2-Pfp ester is a noncleavable antibody-drug conjugate (ADC) linker that falls under the category of polyethylene glycol (PEG) linkers.

Methyltetrazine-Ph-PEG4-azide is a PEG-based azide linker for PROTAC synthesis[1].

Ald-Ph-amido-PEG24-acid is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker employed in PROTACs synthesis[1].

Ald-Ph-amido-PEG1-C2-Pfp ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for PROTACs synthesis[1].

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Dox-Ph-PEG1-Cl, also referred to as PROTAC Linker 34, is a PEG-based compound employed for the synthesis of PROTACs[1].

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker utilized in the formation of antibody-drug conjugates (ADCs).

Tetrazine-Ph-PEG5-NHS ester is a PEGylated N-hydroxysuccinimide (NHS) ester molecule that serves as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-derived linker for PROTACs synthesis.

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker utilized for PROTACs synthesis[1].

Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound that features a cereblon (CRBN) ligand, functioning as an E3 ubiquitin ligase, along with a linker. It can be utilized to create the PROTAC MD-224[1].

Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG4-based linker for PROTACs synthesis[1].

Tetrazine-Ph-OPSS is an ADC linker employed for synthesizing ADCs, or antibody-drug conjugates [1].

NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based compound utilized for the synthesis of PROTACs. [1]

Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed in ADC synthesis[1].

Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker commonly employed for synthesizing PROTACs[1].

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1].

Ald-Ph-amido-PEG3-C1-Boc is a polyethylene glycol (PEG) linker specific to antibody-drug conjugates (ADC).

Ald-Ph-PEG24-TFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG23-OPSS is a cleavable 23-unit polyethylene glycol linker commonly employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Ald-Ph-amido-C2-PEG2-amine is a polyethylene glycol (PEG)-based linker utilized for the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and is an FGF21-receptor agonist. It is also suitable for development as a potential treatment for T2DM.

Ald-Ph-amido-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Mal-NO2-Ph-PEG12-NHS is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].

Ald-Ph-amido-PEG2-C2-Pfp ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.