thiol-peg8-acid

Thiol-PEG8-acid, a PEG-based linker for PROTACs, facilitates the conjugation of two essential ligands necessary for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Thiol-PEG6-acid is a PEG-based linker for PROTACs, joining two essential ligands vital for PROTAC molecule formation. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker used in PROTAC synthesis [1].

Thiol-C9-PEG4-acid is a PEG-based linker for PROTACs that facilitates the conjugation of two essential ligands, playing a crucial role in the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG-thiol (MW 20000) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Thiol-PEG12-acid, a PEG-based linker for PROTACs, joins two essential ligands necessary for PROTAC molecule formation and facilitates selective protein degradation through the ubiquitin-proteasome system within cells.

Amine-PEG-thiol (MW 3400) is a polyethylene glycol (PEG)-based linker with both an amine group and a thiol group, crucial in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Thiol-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker used for the synthesis of PROTACs[1].

Thiol-PEG5-acid is a PEG-based linker for PROTACs that connects two essential ligands indispensable for the formation of PROTAC molecules, facilitating selective protein degradation using the ubiquitin-proteasome system within cells.

Thiol-PEG4-acid is a PEG-based linker for PROTACs, joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG-CH2COOH (MW 3400) is a Polyethylene Glycol (PEG) derivative used as a PROTAC linker for PROTAC synthesis[1].

Thiol-PEG3-phosphonic acid is a PEG-based linker compound used in PROTAC synthesis [1].

Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

m-PEG-thiol (MW 2000) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG-thiol (MW 10000) is a PEG-based linker for PROTACs that joins two critical ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG3-phosphonic acid ethyl ester, a PEG-based linker, serves as a valuable component in the synthesis of PROTACs[1].

m-PEG-thiol (MW 5000) is a PEG-based linker used in PROTACs, facilitating the conjugation of essential ligands necessary for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Thiol-PEG3-acid, a PEG-based linker for PROTACs, facilitates the connection of two essential ligands to form PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker primarily used for the synthesis of PROTACs[1].

Thiol-PEG-CH2COOH (MW 5000) is a polyethylene glycol (PEG) derivative frequently used in the construction of PROTACs, bifunctional compounds designed for targeted protein degradation [1].