uracil 1-b-d-arabinofuranoside

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

1-beta-D-Arabinofuranosyluracil (Uracil 1-β-D-arabinofuranoside), isolated from the Caribbean sponge [Tectitethya crypta], is a methoxyadenosine derivative with anti-inflammatory activity, analgesic, and vasodilation properties.

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a fluoro-modified nucleoside, specifically an Arabino-nucleoside.

AChE BChE MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively. [AChE BChE MAO-B-IN-1] had a neuroprotective effect and was not significantly cytotoxic.

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride (1-PPZ-DHC) is a compound used as a molecular structural unit. It is an analog of the natural product piperazine and has a wide range of biological activities, including anti-inflammatory, anti-tumor and antibacterial activities. It has also been studied for the treatment of neurological disorders such as Alzheimer's and Parkinson's.

[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).

Dynorphin B (1-13) acetate acts as an agonist on opioid κ-receptor.

Kaempferol-3-O-β-D-glucosyl(1-2)rhamnoside is a natural peoduct isolated from Arabian jasmine

D-JNKI-1 acetate (AM-111 acetate) is a highly potent and cell-permeable peptide inhibitor of JNK.

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.

(2S)-1-O-p-coumaroyl-2-O-acetyl-3-O-β-D-glucopyranosylglycerol is a useful research compound for many research applications, including the fields of chemistry and life sciences, among others.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog.

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

(25R)-3β,17α-dihydroxy-5α- spirostan-6-one3-O-α-L- rhamnopyranosyl-(1→2)-β- D-glucopyranoside is a natural product isolated from the bulbs of Lilium brownii var. viridulum.

1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.

MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases.

Complement factor D-IN-1 is a potent and selective small-molecule reversible Factor D inhibitor, with IC50 values of 0.006 μM in the FD Thioesterolytic Fluorescent Assay and 0.05 μM in the MAC Deposition Assay.

Pseudolaric acid B β-D-glucoside (Pseudolaric acid B-glucopyranoside) is a natural product derived from Pseudolarix amabilis.

(-)-Syringaresnol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside ((-)-Syringaresnol-4-O-beta-D-apiofuranos) is a lignan glycoside derived from the bark of Albizzia myriophylla.

B-Raf IN 1 is an inhibitor of B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM).

Genipin 1-β-D-gentiobioside is a natural product for research related to life sciences. The catalog number is T4S2299 and the CAS number is 29307-60-6.

1. Emodin-1-O-β-D-glucopyranoside (Emodin-1-O-glucoside) has neuroprotective and uncoupling activities, and that it may be the a new uncoupler of nNOS-PSD-95. 2. Emodin-1-O-β-D-glucopyranoside shows inhibitory effects on various tumor cells proliferation.

Hederagenin 28-O-{β-D-xylopyranosyl-(1→6)-β-D-glucopyranosyl ester}3-O-{α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} is a saponin known for its antitumor and anti-inflammatory properties [1].

1-(3',5'-dimethoxy)phenyl-2-[4''-O-β-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane showed cytotoxic activities to Hela and hep2 cell lines.

Dynorphin B (1-13) TFA, an agonist of the opioid κ-receptor.

E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid receptor (KOR) agonist [1].

Benzyl [5-O-benzoyl-β-D-apiofuranosyl(1→2)]-β-D-glucopyranoside is a natural product for research related to life sciences. The catalog number is TN5741 and the CAS number is 1097040-08-8.

Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside exhibits antioxidant activity.

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

1-(Piperidin-4-yl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one is a useful organic compound for research related to life sciences and the catalog number is T66378.

(15aR)-1,15-Bis(diphenylphosphino)-7,8,9,10-tetrahydro-6H-dibenzo[b,d][1,6]dioxacycloundecine is a useful organic compound for research related to life sciences and the catalog number is T67391.

Isopentyl b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T126225 and the CAS number is 120671-07-0.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Natural product; inhibitor of protein kinase C

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65682 and the CAS number is 111974-74-4.

2'-Deoxy-2'-fluoro-b-D-arabino-6-azauridine is a Nucleoside Derivative - 6-Aza-uridine; Fluoro-modified nucleoside; Arabino nucleoside.

9-(b-D-Xylofuranosyl)guanine is a Nucleoside Derivative - Xylo-nucleoside.

1-Amino-8-benzyloxy-9-(b-D-xylofuranosyl)guanine is a Nucleoside Derivative - Xylo-nucleoside; 8-Modified purine nucleoside; Amino nucleoside.

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.

α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-D-tyvelose biosynthesis inS. typhi.3Bacterial sucrose phosphorylase converts sucrose and phosphate into D-fructose and α-D-glucose-1-phosphate.4 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen breakdown requires the interplay of several enzymesBiochemistry(2002) 2.Berg, J.M., Tymoczko, J.L., and Stryer, L.Glycogen is synthesized and degraded by different pathwaysBiochemistry(2002) 3.Koropatkin, N.M., and Holden, H.M.Molecular structure of ɑ-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhiJ. Biol. Chem.279(42)44023-44029(2004) 4.Goedl, C., Schwarz, A., Minani, A., et al.Recombinant sucrose phosphorylase from Leuconostoc mesenteroides: Characterization, kinetic studies of transglucosylation, and application of immobilised enzyme for production of ɑ-Ｄ-glucose 1-phosphateJ. Biotechnol.129(1)77-86(2007)

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

2-(((6-(Difluoromethoxy)-1H-benzo[d]imidazol-2-yl)sulfonyl)methyl)-3,4-dimethoxypyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T67420 and the CAS number is 953787-55-8.

N4-Benzoyl-1-(6-O-DMTr-2,3-dideoxy-beta-D-erythro-hexopyranosyl)cytosine is a useful organic compound for research related to life sciences. The catalog number is TNU1623 and the CAS number is 145594-00-9.

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a pyrimidine nucleoside analog, exhibits a broad spectrum of biochemical and anticancer activities, including inhibition of DNA and RNA synthesis, antiviral effects, and immunomodulatory effects [1].

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

Nrf2-ARE hMAO-B QR2 modulator 1, a new resveratrol-based multitarget-directed ligand (MTDL), exhibits a well-balanced MTDL profile: it activates the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibits both hMAO-B and QR2 (IC50s = 8.05 and 0.57 μM), and effectively promotes hippocampal neurogenesis. It exerts neuroprotective and antioxidant actions in both acute and chronic Alzheimer models using hippocampal tissues.