uzh 1

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor with an IC50 of 280 nM, while UZH1b (IC50=28 μM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes, has antitumor activity, and serves as a chemical probe for studying METTL3[1].

UZH1b, an enantiomer of UZH1a (a METTL3 inhibitor), exhibits substantially reduced activity against METTL3, with an IC50 value of 28 µM [1].

UZH1a is a potent and selective inhibitor of METTL3, with an IC50 of 280 nM. It serves as a tool for the epitranscriptomic modulation of cellular processes, exhibits antitumor activity, and functions as a chemical probe for the study of METTL3[1].