v-0219 hydrochloride

V-0219 hydrochloride, an orally-active positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), is utilized in obesity-associated diabetes research.

(R)-V-0219 hydrochloride, an enantiomer of V-0219, functions as an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It induces calcium fluxes in HEK cells expressing hGLP-1R [1], highlighting its biochemical activity and potential therapeutic applications.

(S)-V-0219 hydrochloride, an enantiomer of V-0219, serves as an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R), enhancing calcium fluxes in HEK cells that stably express hGLP-1R. Additionally, it effectively reduces high glucose levels and suppresses feeding behavior in fasted mice [1].

V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.

(S)-V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S)-V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].

(R)-V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R). It induces calcium fluxes in HEK cells that stably express hGLP-1R [1].

V-9302 hydrochloride is a potent and selective competitive antagonist that inhibits transmembrane glutamine flux by specifically targeting the amino acid transporter ASCT2 (SLC1A5), and not ASCT1. In HEK-293 cells, V-9302 hydrochloride effectively inhibits ASCT2-mediated glutamine uptake with an IC50 value of 9.6 μM.