valone

Valone is an anticoagulant.

Chevalone B is a meroterpenoid originally isolated from the fungus E. chevalieri. It is cytotoxic to KB and NCI-H187 cells with IC50 values of 2.9 and 9.8 μg/ml, respectively.

Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.

Chevalone E, a meroterpene identified in A. similanensis, exhibits significant properties.

Cyclovalone (Beveno) is an orally active synthetic curcumin derivative that inhibits cyclooxygenase and exhibits anti-inflammatory, antitumor, and antioxidant activities [1]. It also inhibits cell proliferation in both normal and malignant prostatic cells [2].