vitamin k3 sodium bisulfite

Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement.

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

3-Indoleacetic acid sodium (Heteroauxin sodium salt) is a naturally occurring plant hormone of the auxin class. It can stimulate cell elongation and division, promoting plant growth and development. However, at high concentrations, it exhibits growth inhibiting effects, including epinasty and prevention of shoot and root growth. This latter effect formed the basis for which synthetic auxins were developed as herbicides and bioregulators in agriculture.

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates.

Estrone-d4 3-Sulfate Sodium Salt is a deuterated compound of Estrone 3-Sulfate Sodium Salt. Estrone 3-Sulfate Sodium Salt has a CAS number of 438-67-5.

Phenol, 3-methyl-, sodium salt (1:1) is a bioactive chemical.

1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-glycerol sodium salt is a useful organic compound for research related to life sciences and the catalog number is T67071.

Sodium 3-hydroxybenzoate is a bioactive chemical.

Vitamin K3-d8 is a deuterated compound of Vitamin K3.

DMPA, a derivative of phosphatidic acid (PA), constitutes a significant component of cellular membranes.

3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating uncoupling protein 1 (UCP-1) and CIDEA expression. Additionally, it boosts PPARα expression in both primary adipocytes and mouse inguinal white adipose tissue (WAT) in vivo, alongside enhancing β-oxidation in hepatocytes. Its plasma levels surge post-exercise in mice, and its administration at 100 mg/kg daily curtails weight gain and body fat without diminishing food consumption or hiking energy output, whilst ameliorating glucose tolerance. Notably, 3-aminoisobutyric acid concentrations are heightened in individuals with β-ureidopropionase deficiency, a genetic flaw impairing pyrimidine degradation, affecting plasma, urine, and cerebrospinal fluid.

1,2-Dilauroyl-sn-glycero-3-phospho-(2R)-glycerol is a type of phosphoglycerol characterized by the presence of lauric acid at the sn-1 and sn-2 positions. [Matreya, LLC. Catalog No. 1443]

3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.

Sodium 3-methyl-2-oxobutanoate, a precursor of pantothenic acid in Escherichia coli, can be enhanced in vitro along with alpha-ketoisocaproic (ac).

1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is an endogenous human metabolite.

Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.

Uridine-3'-monophosphate is a nucleoside used in the biochemical synthesis of ribothymidine-3'-phosphate. It has been used as a bioavailable source of uridine in research studies designed to enhance learning and memory.

Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated miceToxicol. Sci.161(1)34-47(2018)

3'-Amino-3'-deoxyguanosine-5'-O-triphosphate (3'-amino-dGTP), an amine-modified nucleotide, effectively terminates RNA strand synthesis as catalyzed by RNA polymerase in E. coli. This compound has also been utilized in creating a non-hydrolyzable derivative of the alarmone guanosine pentaphosphate (pppGpp).

Vitamin K3-d3 is a deuterated compound of Vitamin K3. Vitamin K3 has a CAS number of 58-27-5. Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.

Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .

3-Hydroxypropionic Acid sodium salt can be used to synthesize some degradable plastics and produce a series of C3 compounds.

1,2-Dilauroyl-sn-glycero-3-PG (sodium salt) is a useful organic compound for research related to life sciences. The catalog number is T64559 and the CAS number is 322647-27-8.

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

Adenosine 3',5'-diphosphate sodium salt is an inhibitor of hydroxysteroid sulfotransferases, which are adenine nucleotides containing a phosphate group at the 3' and 5' positions of the pentose ribose.Adenosine 3',5'-diphosphate (sodium salt) is the product of 3'-phosphoadenosine 5'-phosphosulfonate (PAPS), a cofactor of sulfotransferases (SULTs). diphosphate disodium is the product of 3'-phosphoadenosine 5'-phosphosulfonate (PAPS), a cofactor for sulfotransferases (SULTs), which has been used to study the kinetic properties and structure of SULTs.

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium), an anionic phospholipid, is used in drug delivery systems and liposome synthesis [1].

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product obtained through NADPH oxidase activation and Lyso-PS signal transduction. This compound utilizes macrophage G2A function to enhance the receptor ligand system, thereby resolving neutrophil inflammation.

1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion [1].

Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphatidyl inositol (PI)-specific kinases.

Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).

Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women. 1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual cycleSteroids63(1)5-13(1998) 2.Adlercreutz, H., Brown, J., Collins, W., et al.The measurement of urinary steroid glucuronides as indices of the fertile period in womenJ. Steroid Biochem.17(6)695-702(1982)

K 259-3, a methyl ester of K 259-2, is an inhibitor of calmodulin-dependent cyclic nucleotide phosphodiesterase.

Adenosine-5'-O-(3-thiotriphosphate) (ATPγS), an agonist of the purinergic P2Y11 receptor, prompts inositol phosphate accumulation in CHO-K1 cells harboring the human or canine P2Y11 receptor with EC50 values of 1.2 and 19.3 µM, respectively. At a concentration of 10 µM, ATPγS mitigates Junin virus-induced mRNA boosts pertaining to bone morphogenetic protein 6 (BMP6) and diminishes particle forming units (PFUs) in infected primary rat osteoblasts. Furthermore, when applied at 25 µM, it triggers insulin secretion in MIN6 pancreatic β-cells.

DLPA is a phosphatidic acid (PA) that incorporates the medium-chain lauric acid (12:0).

1-Stearoyl-2-hydroxy-sn-glycero-3-PG, a lysophospholipid characterized by the presence of stearic acid (18:0) at the sn-1 position, finds application in the creation of micelles, liposomes, and various artificial membranes, including those utilized in lipid-based drug delivery systems.

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)) can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors. It has been utilized in the formation of unilamellar vesicles to study membrane structure curvature and in supported lipid bilayers to examine the impact of various support materials on lipid redistribution between membrane leaflets.

1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (T64571) is a natural product utilized in life sciences research.

3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in U87MG cells.

(R)-3-Hydroxybutanoic acid sodium, catalog number T67002, is a natural product used for research in life sciences.

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]

3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite found in type I diabetic patients that regulates membrane lipids.

3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt) can be used in related research in the field of life sciences. Its product number is T36135 and CAS number is 1346603-21-1.

(S)-3-Hydroxybutyrate (sodium salt) is a useful organic compound for research related to life sciences. The catalog number is T67018 and the CAS number is 127604-16-4.

Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin.

Cathepsin K Inhibitor 3, exhibiting an IC50 value of 0.5 nM, is a highly selective inhibitor of cathepsin K, featuring a favorable pharmacokinetic profile. It holds potential for use in studies of osteoarthritis (OA).

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

D-Fructose-1,6-bisphosphate sodium salt hydrate is the intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is produced by phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction mediated by fructose-1, 6-diphosphatase-1 is one of the rate-limiting steps of gluconeogenesis. The same reaction occurs in the chloroplasts of plants, D-Fructose-1,6-bisphosphate sodium salt hydrate as part of the reducing pentose phosphate cycle. Since cancer cells use glycolysis as a primary source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.

Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).