vitamin-b1

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

Thiamine monochloride (Vitamin B1) is an essential vitamin with erythropoietic, glucose-regulatory, antioxidant, and mood-regulatory properties. It inhibits lead-induced lipid peroxidation, preventing lead poisoning, and plays a crucial role in cellular energy production from ingested food while enhancing normal neuronal activity.

Thiamine hydrochloride (Vitamin B1) is the hydrochloride salt form of thiamine, a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Upon hydrolysis, Thiamine hydrochloride (Vitamin B1) is phosphorylated by thiamine diphosphokinase to form active thiamine pyrophosphate (TPP), also known as cocarboxylase. TPP is a coenzyme for many enzymatic activities involving fatty acid, amino acid and carbohydrate metabolism.

Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives.

AChE BChE MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE, and MAO-B that crosses the blood-brain barrier, exhibiting inhibitory effects on hAChE, hBChE, and hMAO-B with IC50s of 7.31, 0.56, and 26.1 μM, respectively. [AChE BChE MAO-B-IN-1] had a neuroprotective effect and was not significantly cytotoxic.

Dynorphin B (1-13) acetate acts as an agonist on opioid κ-receptor.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases.

B-Raf IN 1 is an inhibitor of B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM).

Vitamin B1 Pyrophosphate-d3 is a deuterated compound of Vitamin B1 Pyrophosphate.

Dynorphin B (1-13) TFA, an agonist of the opioid κ-receptor.

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

Nucleoside Derivatives - 7-Deaza-purine nucleosides; Natural product; inhibitor of protein kinase C

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65682 and the CAS number is 111974-74-4.

1-Amino-8-benzyloxy-9-(b-D-xylofuranosyl)guanine is a Nucleoside Derivative - Xylo-nucleoside; 8-Modified purine nucleoside; Amino nucleoside.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

Nrf2-ARE hMAO-B QR2 modulator 1, a new resveratrol-based multitarget-directed ligand (MTDL), exhibits a well-balanced MTDL profile: it activates the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibits both hMAO-B and QR2 (IC50s = 8.05 and 0.57 μM), and effectively promotes hippocampal neurogenesis. It exerts neuroprotective and antioxidant actions in both acute and chronic Alzheimer models using hippocampal tissues.

Dual AChE-MAO B-IN-1 (compound 15) is a safe, metabolically stable neuroprotective agent. This potent, orally active, CNS-permeable inhibitor demonstrates IC50 values of 550 nM for human AChE and 8.2 nM for MAO-B, indicating low in vitro activity against these enzymes.

Cbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation.

UT-B-IN-1 (UTBINH-14) is a reversible, competitive, and selective inhibitor of the urea transporter-B (UT-B) with IC50 values of 10 nM and 25 nM for human and mouse UT-B, respectively. It exhibits low toxicity and superior selectivity against UT-B compared to UT-A isoforms, enhances urine production, and decreases urine concentration in mice, making it suitable for research on diuretic mechanisms.

1-(b-D-Xylofuranosyl)-N6-(p-methoxybenzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside.

1-(2-C-b-Methyl-b-D-ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyridine nucleoside; 2'-C-Methyl nucleoside.

DNA gyrase B-IN-1 is a potent inhibitor of DNA gyrase B, exhibiting good binding affinity and stability. DNA gyrase B-IN-1 inhibits P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM).

5-(11bR)-Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64437.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

1-(b-D-Xylofuranosyl)-N6-(m-trifluoromethyl benzyl) adenine is a Nucleoside Derivative - Xylo-nucleoside, 6-Modified purine nucleoside, Fluoro-modified nucleoside.

CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor agonist and has the potential of reducing the secretion of gastric acid.

CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31-B interferes with the association between Plasmodium falciparum eIF4A (PfeIF4A) and RNA. Additionally, CR-1-31-B induces apoptosis in neuroblastoma and gallbladder cancer cells [4].

1-Hydroxymethyl-b-carboline is a useful organic compound for research related to life sciences. The catalog number is T125583 and the CAS number is 17337-22-3.

Nucleoside Derivatives - Xylo-nucleosides, Thio-nucleosides

Dyrk1A B-IN-1 (compound 3n) is a potent, selective, and cell-permeable inhibitor of DYRK1A and DYRK1B, with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.

(11aR)-5-(4,5,6,7-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-5H-dibenzo[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64513.

1-Deacetylnimbolinin B is a natural product from Melia toosendan Sieb. et Zucc.

PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.

Dynorphin B (1-13) acts as an agonist on the opioid κ-receptor.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1039.

(11AS)-5-(4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-yl)-5H-dibenzo[b,f]azepine is a useful organic compound for research related to life sciences and the catalog number is T64639.

1-(b-D-Ribofuranosyl)-5-nitropyridine-2(1H)-one is a Pyrimidine nucleoside.

1-(b-D-Xylofuranosyl)-6-azauracil is a Nucleoside Derivative - Xylo-nucleoside; 6-Aza-uridine.

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a polyethylene glycol-based PROTAC linker used in the synthesis of PROTACs.

Factor B-IN-1 is a Factor B inhibitor (IC50 = 43 nM) and is an analog of compound 13. It is used to inhibit complement pathway factor B and has improved pharmacokinetic properties (oral availability in rats and dogs).

Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule designed for synthesizing proteolysis-targeting chimeras (PROTACs).

ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells.

Nucleoside Derivatives - 7-Deaza-8-aza-purine nucleosides,6-Modified purine nucleosides; Scaffolds and Templates

1-(b-D-Xylofuranosyl)uracil is a Nucleoside Derivative - Xylo-nucleoside.

1-(b-D-Xylofuranosyl)-5-fluorouracil is a nucleoside derivative, specifically a xylo-nucleoside and fluoro-modified nucleoside, characterized by a 5-modified pyrimidine nucleoside structure.