vps34 in 1

Vps34-IN-1 (VPS34-IN1) is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM in vitro, which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.

HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) is a 17-amino acid peptide with anti-HIV-1 activity, derived from the Rev-responsive element-binding domains of Rev in HIV-1.

VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.

VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)

Human PTHrP-(1-34)NH2, also known as PTH-Related Protein (1-34) amide for human, mouse, and rat, is the N-terminal fragment of PTHrP. This peptide induces hypercalcemia and is utilized in the study of humoral hypercalcemia of malignancy [1].

Parathyroid Hormone (1-34), bovine, a parathyroid hormone (PTH) receptor agonist from the parathyroid hormone family, is used to study osteoporosis and hypoparathyroidism.

This is a fragment of beta-amyloid peptide. It has amino acids 1 through 34.

GLP-2 (1-34) (human), a polypeptide secreted from the intestine shortly after eating, is used in research related to bone remodeling processes [1].

HIV-1 inhibitor-34 (compound 5q) is a potent and selective HIV-1 inhibitor, with an EC50 of 6.4 nM for HIV-1 and a CC50 of 16 μM in MT-4 cells, making it useful for AIDS research.

Parathyroid Hormone (1-34), human, biotinylated is a probe targeting the parathyroid hormone receptor, used to analyze parathyroid hormone-receptor interactions within living cells and to purify hormone-receptor complexes via affinity columns [1] [2].

Parathyroid hormone (1-34) (rat) (acetate) is a variant that enhances the structure of cortical and cancellous bones and is utilized in osteoporosis research [1] [2].

PD-1 PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1 PD-L1 interaction (IC50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1 (KD = 0.1554 μM), resulting in the activation of the immune microenvironment and suppression of tumor growth [1].

Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.

Parathyroid Hormone (1-34), bovine TFA, a potent agonist of the parathyroid hormone (PTH) receptor, elevates calcium and inorganic phosphate levels in vivo and is used in osteoporosis research [1].

Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L. It impedes the formation of complex I in the lipid kinase VPS34, thus inhibiting autophagy, while leaving complex II intact, which relies on the Beclin 1-UVRAG interaction for its integrity and is essential for vesicle transport [1].