xl-147 derivative 1

L-Threonine derivative-1 is acetylsalicylic acid-L-threonine ester with potential analgesic activity.

Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.

Kobusine derivative-1, a variant of Kobusine, exhibits antiproliferative effects on cancer cells [1].

Pyridazinediones-derivative-1 shows potential in the treatment of neurodegenerative disorders.

Heterocyclyl carbamate derivative 1, a heterocyclyl carbamate derivative, is used for the research of neurological diseases and inflammatory.

Benzylbenzofuran Derivative-1 (Compound 8), a benzylbenzofuran derivative, is isolatable from Silene conoidea [1].

OT antagonist 1 demethyl derivative, a demethyl derivative of OT antagonist 1, is a selective Oxytocin antagonist with a Ki of 50 nM.

Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis.

Compound 72-1, also known as BCL-xL BCL-2 ligand 1, serves as a ligand for BCL-xL and BCL-2 proteins. It can be tethered to an E3 ligase via a linker, facilitating the formation of PROTACs [1] [2].

Ebselen derivative 1 (Compound 19), an orally active glutathione peroxidase (GPx) mimic, exhibits notable protective effects against cisplatin-induced hair cell (HC) damage in both in vitro and in vivo settings. It significantly reduces oxidative stress, apoptosis, and ferroptosis in hair cells, making it useful in the study of cisplatin-induced hearing loss [1].

PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].

PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits toxicity towards human platelets and MyLa 1929 cells, with IC50 values of 62 nM and 8.5 μM, respectively [1].

Cyclosporin A-Derivative 1 (Free base) is a crystalline intermediate obtained from cyclosporin A via ring-opening.

Carbazole derivative 1 is used to reduce androgen or oestrogen levels in mammals.

Diarylalkane derivative 1 is utilized in pancreatitis research.

Benzamide Derivative 1 Benzamide derivative with gastrokinetic activity.Benzamide Derivative 1 can be used in the study of gastrointestinal diseases.

Hemiasterlin Derivative-1, a derivative of hemiasterlin, is utilized in the synthesis of Antibody-Drug Conjugates (ADC).

Oleanolic acid derivative 1 is a modified form of oleanolic acid.

Glycerol derivative 1 is a compound named [(1R)-1-[(2S)-2-(hexadecanoyloxy)-3-(hexadecanoyloxy)propoxy]-1-(hydroxymethyl)ethyl] hexadecanoate, characterized as odorless and tasteless. It appears as a white or cream-colored powder and is insoluble in water, but highly soluble in (methanol).

Cyclosporin A-Derivative 1, a crystalline intermediate, is derived from the opening of cyclosporin A.

Exendin derivative 1, a 39-amino acid peptide, is a chemical compound known for its significant biological activity and therapeutic potential.

PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.