ym298198 hydrochloride

mGlu1 receptor antagonist

YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). YM 298198 Hydrochloride is inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). It inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively).

Desmethyl-YM-298198 is a highly affine, selective, non-competitive antagonist of mGluR1 (IC50: 16 nM). It demonstrates analgesic effects in mice with pain hypersensitivity induced by Streptozotocin.

inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX)

YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

mGlu1-selective antagonist

Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits the survivin promoter with an IC₅₀ of 0.54 nM[1].