z-vad(ome)-fmk

Z-VAD(OMe)-FMK is a pan-caspase inhibitor with irreversible properties; Z-VAD(OMe)-FMK is also an inhibitor of ubiquitin C terminal hydrolase L1 (UCHL1), which is irreversibly modified by targeting the UCHL1 active site.

Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not inhibit UCHL1 activity, even at concentrations up to 440 μM.

Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.

When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluorometh

AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.

Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a cell-permeable, selective inhibitor of caspase 8.

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.[2]

Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.

Z-LEED-FMK is a chemical compound that acts as an inhibitor for caspase-13 and caspase-4. Additionally, it impedes caspase-1 processing in S. typhimurium-infected macrophages [1] [2].

Z-Gly-OMe is a useful organic compound for research related to life sciences. The catalog number is T66677 and the CAS number is 1212-53-9.

Z-DEVD-FMK, a Caspase-3 Inhibitor, is an irreversible, cell-permeable inhibitor of caspase-3/CPP32 that impedes tumor cell apoptosis. In vivo studies show it offers neuroprotection in rat hippocampi post-seizures and considerably diminishes post-traumatic apoptosis, enhancing neurological recovery in rats before and after traumatic brain injury induction.

Z-VRPR-FMK, an irreversible inhibitor of the MALT1 protein, effectively suppresses the proliferation and invasion of diffuse large B-cell lymphoma. This is achieved through the inhibition of MALT1-induced NF-κB activation and MMP (matrix metalloproteinase) expression.

Z-Ser(Tos)-OMe is an amino acid derivative and has a wide range of applications in life science related research.

Z-LEHD-FMK is a selective and potent caspase-9 inhibitor that protects against reperfusion injury and slows apoptosis. Z-LEHD-FMK exhibits antitumor and neuroprotective activity, increases the yield of in vitro-produced preimplantation embryos of [Bubalus bubalis], and alters the cellular stress response.

Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, providing protection against detrimental reperfusion injury and moderating apoptosis, with demonstrated neuroprotective potential in a rat model of spinal cord trauma.

Z-VRPR-FMK (TFA), a selective and irreversible inhibitor of Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), is a tetrapeptide shown to provide protection against influenza A virus (IAV) infection [1].

Z-Ala-OMe is a useful organic compound for research related to life sciences. The catalog number is T66749 and the CAS number is 28819-05-8.

Z-VAD-AMC is a fluorogenic substrate for caspase-1. Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.

Z-VDVA-(DL-Asp)-FMK, a derivative of Z-VDVAD-FMK, is specifically designed as a caspase-2 inhibitor.

Z-VAE(OMe)-fmk is a cell-permeable and irreversible UCHL1 inhibitor. The inhibitor approaches the active-site cleft from the opposite side of the crossover loop as compared to the direction of approach of ubiquitin's C-terminal tail, thereby occupying the P1' (leaving group) site, a binding site perhaps used by the unknown C-terminal extension of ubiquitin in the actual in vivo substrate(s) of UCHL1.

Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible inhibitor of lymphoma translocation protein 1 (MALT1) in mucosa-associated lymphoid tissue.

Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1 5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).

Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.

Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, effectively preventing cellular apoptosis.

Z-LLY-FMK (Calpain Inhibitor IV) inhibits calpain, a family of proteases involved in the apoptosis of various cell systems, and specifically suppresses intestinal cell apoptosis following common bile duct ligation [1].

Z-LEVD-FMK, a cell-permeable caspase-4 inhibitor, effectively blocks endoplasmic reticulum (ER) stress-induced apoptosis in cancer cells.

(Rac)-Z-Phe-Phe-FMK (Cathepsin L-IN-2) is a cathepsin L inhibitor that inhibits the tendency of β-amyloid to induce apoptotic changes .

Z-Asp(OMe)-OH is a useful organic compound for research related to life sciences. The catalog number is T65922 and the CAS number is 3160-47-2.

Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.